Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 157, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2023.103924
Keywords
Angiotensin-converting enzyme; Birth weight; Placental growth factor; Preeclampsia; Vascular endothelial growth factor
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This study investigated the association of ACE insertion/deletion (I/D) polymorphism with preeclampsia (PE) in Tunisian women. ACE I/D genotyping was performed and no significant difference in alleles and genotypes was observed between women with PE and control women. However, a significant difference in the frequency of the I/I genotype was seen between the two groups, with carriers of the I/I genotype having higher infant birth weights. The study also found a dose-dependent relationship between ACE I/D genotypes and VEGF and PlGF plasma levels. Furthermore, a positive correlation between PAC and PIGF was found. These findings suggest a potential role for ACE I/D polymorphism in the pathogenesis of PE and highlight the relationship between PAC and PlGF.
We investigated the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism with preeclampsia (PE) in Tunisian women. ACE I/D genotyping was done by PCR in 342 pregnant women with PE and 289 healthy pregnant women. The association between ACE I/D and PE and associated features were also evaluated. Decreased active renin concentration, plasma aldosterone concentration, and placental growth factor (PlGF) were observed in PE cases, while soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio was significantly higher in the PE group. Distribution of ACE I/D alleles and genotypes were comparable between women with PE and control women. A significant difference in the frequency of the I/I genotype was seen between PE cases and control women according to the recessive model, with a trend towards association in the codominant model. Carriers of the I/I genotype had significantly higher infant birth weights compared to the I/D and the D/D genotype carriers. A dose-dependent relationship was also seen in VEGF and PlGF plasma levels and specific ACE I/ D genotypes, with the lowest VEGF levels seen in the I/I genotype carriers compared to the D/D genotype carriers. Similarly, the I/I genotype carriers had the lowest PlGF levels compared to I/D and D/D genotype carriers. Furthermore, when studying the linkage between PE features, we found a positive correlation between PAC and PIGF. Our study suggests a role for ACE I/D polymorphism in the pathogenesis of PE, possibly through modulating VEGF and PlGF levels and infant birth weight, and highlights the relationship between PAC and PlGF.
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