Evaluation of [99mTc]Tc-TTHMP as a SPECT imaging agent for skeletal system

TTHMP (triethylene-tetramine-hexamethylene-phosphonic acid) shows good bone-seeking ability in previous studies. In this research, [Tc-99m]Tc-TTHMP was prepared with the radiochemical yield of 98% and the possible application of [Tc-99m]Tc-TTHMP in skeletal system imaging was evaluated. The corresponding TTHMP kits have also been developed. [Tc-99m]Tc-TTHMP is hydrophilic and stable in saline and serum. The biodistribution data show [Tc-99m]Tc-TTHMP has a high uptake in the bone and is excreted rapidly through urinary system. Both micro-SPECT/CT imaging in normal mice and SPECT imaging in a normal Beagle dog confirm the results. It is suggested that [Tc-99m]Tc-TTHMP can be a candidate for skeletal system imaging.

Automated summary

TTHMP has been found to have good bone-seeking ability in previous studies. In this research, [Tc-99m]Tc-TTHMP was prepared and evaluated for its potential application in skeletal system imaging. Corresponding TTHMP kits were also developed. The biodistribution data showed high uptake of [Tc-99m]Tc-TTHMP in the bone and rapid excretion through the urinary system. Micro-SPECT/CT imaging in normal mice and SPECT imaging in a normal Beagle dog confirmed the results. It is suggested that [Tc-99m]Tc-TTHMP can be a candidate for skeletal system imaging.