4.7 Article

Optimizing a Diagnostic Model of Periodontitis by Using Targeted Proteomics

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Targeted proteomics improves cardiovascular risk prediction in secondary prevention

Nick S. Nurmohamed et al.

Summary: The study demonstrates that a proteome-based risk model outperforms a clinical risk model in predicting recurrent ASCVD events. Neutrophil-related pathways were associated with cardiovascular events in low CRP patients, indicating residual inflammatory risk beyond traditional pathways.

EUROPEAN HEART JOURNAL (2022)

Review Dentistry, Oral Surgery & Medicine

Impact of the treatment of periodontitis on systemic health and quality of life: A systematic review

Marco Orlandi et al.

Summary: Treatment of periodontitis can lead to improvements in systemic health, including reduction in cardiometabolic risk, systemic inflammation, and preterm deliveries. Further research is needed to confirm the sustainability of these changes, and future clinical trials should include appropriate quality of life outcomes in their study designs.

JOURNAL OF CLINICAL PERIODONTOLOGY (2022)

Article Medical Laboratory Technology

Novel associations between inflammation- related proteins and adiposity: A targeted proteomics approach across four population- based studies

Mariana Ponce-de-Leon et al.

Summary: This study investigated the association between obesity and inflammation-related proteins in European populations and identified 14 novel proteins associated with adiposity. The majority of these proteins were found to be associated with visceral fat and adipose tissue accumulation in the abdomen and trunk.

TRANSLATIONAL RESEARCH (2022)

Article Dentistry, Oral Surgery & Medicine

Association between bone turnover markers and periodontitis: A population-based cross-sectional study

Stefan Lars Reckelkamm et al.

Summary: This study reveals positive associations of N-procollagen type 1 amino-terminal propeptide, bone-specific alkaline phosphatase, and sclerostin with periodontitis, while wingless-type mouse mammary tumor virus integration site family member 5a showed an inverse association. However, the results are contradictory in the overall context and previous associations reported in other studies could not be confirmed.

JOURNAL OF CLINICAL PERIODONTOLOGY (2022)

Review Dentistry, Oral Surgery & Medicine

Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications

George Hajishengallis

Summary: Periodontitis is linked with various other diseases, potentially with a causal relationship. Interventional studies and preclinical models support the connection between periodontitis and comorbidities, providing mechanistic insights. Advances in understanding the periodontitis-systemic disease connection may lead to innovative therapeutic options for reducing the risk of periodontitis-linked comorbidities.

PERIODONTOLOGY 2000 (2022)

Article Dentistry, Oral Surgery & Medicine

Salivary and serum markers of angiogenesis in periodontitis in relation to smoking

Cigdem Yilmaz Sastim et al.

Summary: This study investigated the concentrations of angiogenesis-related proteins in saliva and serum in relation to smoking and periodontitis. The results showed that concentrations of these proteins were significantly higher in periodontitis patients compared to healthy controls, while smokers had elevated levels of specific proteins in serum compared to nonsmokers.

CLINICAL ORAL INVESTIGATIONS (2021)

Review Medicine, General & Internal

Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis

Carlo Cafiero et al.

Summary: Periodontitis is the primary cause of tooth loss in the industrialized world, diagnosed through a comprehensive check of the patient's periodontal health. Utilizing biomarkers in saliva for early diagnosis is crucial for improving periodontal health worldwide.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Immunology

Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

George Hajishengallis et al.

Summary: Periodontitis is causally linked to the development of other chronic inflammatory diseases outside the oral mucosa, and intervention studies have shown that local treatment of periodontitis can ameliorate surrogate markers of comorbid conditions. Experimental animal studies have further strengthened the potential causal link by establishing biologically plausible and clinically consistent mechanisms. Understanding the impact of disseminated periodontal pathogens and systemic inflammation associated with periodontitis on extra-oral pathologies may lead to new therapeutic options to reduce the risk of periodontitis-associated comorbidities.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention

Renate M. Hoogeveen et al.

EUROPEAN HEART JOURNAL (2020)

Article Immunology

Prediction of Chronic Periodontitis Severity Using Machine Learning Models Based On Salivary Bacterial Copy Number

Eun-Hye Kim et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention

Renate M. Hoogeveen et al.

EUROPEAN HEART JOURNAL (2020)

Article Dentistry, Oral Surgery & Medicine

Development and validation of a predictive model for periodontitis using NHANES 2011-2012 data

Eduardo Montero et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2019)

Article Mathematical & Computational Biology

The Integrated Calibration Index (ICI) and related metrics for quantifying the calibration of logistic regression models

Peter C. Austin et al.

STATISTICS IN MEDICINE (2019)

Article Biochemistry & Molecular Biology

Plasma protein patterns as comprehensive indicators of health

Stephen A. Williams et al.

NATURE MEDICINE (2019)

Article Dentistry, Oral Surgery & Medicine

Staging and grading of periodontitis: Framework and proposal of a new classification and case definition

Maurizio S. Tonetti et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2018)

Review Dentistry, Oral Surgery & Medicine

Prediction models for the incidence and progression of periodontitis: A systematic review

Mi Du et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2018)

Review Dentistry, Oral Surgery & Medicine

Impact of periodontal disease on quality of life: a systematic review

M. C. Ferreira et al.

JOURNAL OF PERIODONTAL RESEARCH (2017)

Review Biochemistry & Molecular Biology

Revisiting biomarker discovery by plasma proteomics

Philipp E. Geyer et al.

MOLECULAR SYSTEMS BIOLOGY (2017)

Article Dentistry, Oral Surgery & Medicine

A Two-Domain Self-Report Measure of Periodontal Disease Has Good Accuracy for Periodontitis Screening in Dental School Outpatients

Georgios S. Chatzopoulos et al.

JOURNAL OF PERIODONTOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Towards better clinical prediction models: seven steps for development and an ABCD for validation

Ewout W. Steyerberg et al.

EUROPEAN HEART JOURNAL (2014)

Editorial Material Public, Environmental & Occupational Health

The Table 2 Fallacy: Presenting and Interpreting Confounder and Modifier Coefficients

Daniel Westreich et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2013)

Review Dentistry, Oral Surgery & Medicine

Risk factors for periodontal disease

Robert J. Genco et al.

PERIODONTOLOGY 2000 (2013)

Article Dentistry, Oral Surgery & Medicine

Update of the Case Definitions for Population-Based Surveillance of Periodontitis

Paul I. Eke et al.

JOURNAL OF PERIODONTOLOGY (2012)

Article Medicine, General & Internal

Global and regional causes of death

Colin D. Mathers et al.

BRITISH MEDICAL BULLETIN (2009)