Journal
JOURNAL OF POLYMERS AND THE ENVIRONMENT
Volume 31, Issue 11, Pages 4738-4751Publisher
SPRINGER
DOI: 10.1007/s10924-023-02913-y
Keywords
Chitosan; Hydrogel; Basil seed gum; Gallic acid; Quercetin-loaded zein microsphere; Tissue engineering
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This study introduces an easy method to produce high strength composite chitosan hydrogel by using Gallic acid as a cross-linking agent. The cross-linked hydrogel shows dense microstructure, good mechanical properties, high porosity, thermal stability, high swelling ratio, high antioxidant activity, and good biocompatibility. Adding quercetin loaded-Zein microsphere in the optimal hydrogel further enhances its characteristics, making it a promising material for tissue engineering.
The chitosan-based hydrogel has high potential in tissue engineering; however, its performance is relatively poor in practice. Here, an easy method is introduced to produce high strength composite chitosan hydrogel. Chitosan (CS) and Basil seed gum (BSG) are converted into a 3-dimensional hydrogel with the assistance of Gallic acid (GA) as a cross-linking agent. The incorporation of GA into CS-BSG hydrogel forms cross-linking bonds (hydrogen bonds) between GA and polymer chains. The experimental results show that the GA cross-linked hydrogel has a dense microstructure, good mechanical properties, high porosity, thermal stability, and a high swelling ratio. With the high antioxidant activity and good biocompatibility, these properties make the GA-crosslinked hydrogel as a promising material for tissue engineering. Furthermore, adding quercetin loaded-Zein microsphere in the optimal hydrogel (the hydrogel containing the highest concentration of GA) proved to have a synergistic effect on the mentioned characteristics of the hydrogel. Cell culture tests confirmed that this scaffold is nontoxic and biocompatible for cell proliferation. The prepared hydrogels hold great potential as a scaffold for tissue engineering applications based on the results.
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