Related references
Note: Only part of the references are listed.Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar
Omozuanvbo Aisiku et al.
BLOOD (2015)
Approval of the first protease-activated receptor antagonist: Rationale, development, significance, and considerations of a novel anti-platelet agent
Shauna L. French et al.
BLOOD REVIEWS (2015)
The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function
Jessica K. Mountford et al.
NATURE COMMUNICATIONS (2015)
PAR1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact
Heather M. Judge et al.
PLATELETS (2015)
Heart Disease and Stroke Statistics-2015 Update A Report From the American Heart Association
Dariush Mozaffarian et al.
CIRCULATION (2015)
Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
Leonard C. Edelstein et al.
BLOOD (2014)
Targeting the anionic region of human protease-activated receptor 4 inhibits platelet aggregation and thrombosis without interfering with hemostasis
M. M. Mumaw et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2014)
On World Thrombosis Day
Frits R. Rosendaal et al.
LANCET (2014)
Thrombin-induced platelet activation via PAR4: pivotal role for exosite II
Niklas Boknas et al.
THROMBOSIS AND HAEMOSTASIS (2014)
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
Leonard C. Edelstein et al.
NATURE MEDICINE (2013)
The PAR1 antagonist, SCH79797, alters platelet morphology and function independently of PARs
Hannah Lee et al.
THROMBOSIS AND HAEMOSTASIS (2013)
Protease-Activated Receptor (PAR) 1 and PAR4 Differentially Regulate Factor V Expression from Human Platelets
Matthew Duvernay et al.
MOLECULAR PHARMACOLOGY (2013)
Platelet secretion is kinetically heterogeneous in an agonist-responsive manner
Deepa Jonnalagadda et al.
BLOOD (2012)
Thrombin generation: What have we learned?
Raed Al Dieri et al.
BLOOD REVIEWS (2012)
Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice
H. Lee et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse
J. D. Welsh et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)
Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes
Pierluigi Tricoci et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Vorapaxar in the Secondary Prevention of Atherothrombotic Events
David A. Morrow et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions
Hannah Lee et al.
THROMBOSIS AND HAEMOSTASIS (2012)
Protease-activated receptor 1 (PAR1) signalling desensitization is counteracted via PAR4 signalling in human platelets
Knut Falker et al.
BIOCHEMICAL JOURNAL (2011)
A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia
Lacramioara Ivanciu et al.
NATURE BIOTECHNOLOGY (2011)
Combined blockade of thrombin anion binding exosite-1 and PAR4 produces synergistic antiplatelet effect in human platelets
Chin-Chung Wu et al.
THROMBOSIS AND HAEMOSTASIS (2011)
The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation
Chin-Chung Wu et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease
Shinya Goto et al.
EUROPEAN HEART JOURNAL (2010)
Deficiency of PAR4 attenuates cerebral ischemia/reperfusion injury in mice
Yingying Mao et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)
Annexin V binding to platelets is agonist, time and temperature dependent
Sofia Ramstrom et al.
PLATELETS (2010)
Protease-activated receptors as targets for antiplatelet therapy
Justin R. Hamilton
BLOOD REVIEWS (2009)
Angiogenesis is regulated by a novel mechanism:: pro- and antiangiogenic proteins are organized into separate platelet α granules and differentially released
Joseph E. Italiano et al.
BLOOD (2008)
Protease-activated receptor-induced Akt activation -: regulation and possible function
J. C. Resendiz et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases
E. E. Gardiner et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis
Bryan Voss et al.
MOLECULAR PHARMACOLOGY (2007)
Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis
Erik R. Vandendries et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation
Michael Holinstat et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis
AJ Leger et al.
CIRCULATION (2006)
Synergistic effect of thrombin on collagen-induced platelet procoagulant activity is mediated through protease-activated receptor-1
JFW Keuren et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Proteinase-activated receptor-4:: Evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo
MD Hollenberg et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets
JR Hamilton et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)
Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency
E Camerer et al.
BLOOD (2004)
Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage
SL Jacques et al.
BIOCHEMICAL JOURNAL (2003)
Inhibition of platelet thromboxane receptor function by a thrombin receptor-targeted pepducin
JJ Stampfuss et al.
NATURE MEDICINE (2003)
Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells
H Kataoka et al.
BLOOD (2003)
Calibrated automated thrombin generation measurement in clotting plasma
HC Hemker et al.
PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS (2003)
Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation
L Covic et al.
NATURE MEDICINE (2002)
Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides
L Covic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Role of thrombin signalling in platelets in haemostasis and thrombosis
GR Sambrano et al.
NATURE (2001)
Thrombin signalling and protease-activated receptors
SR Coughlin
NATURE (2000)
Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin
MJ Shapiro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
YD-3, a novel inhibitor of protease-induced platelet activation
CC Wu et al.
BRITISH JOURNAL OF PHARMACOLOGY (2000)
Structure-function analysis of protease-activated receptor 4 tethered ligand peptides - Determinants of specificity and utility in assays of receptor function
TR Faruqi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets
L Covic et al.
BIOCHEMISTRY (2000)
Share Paper
