Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1113/JP283719
Keywords
homeostatic plasticity; ion channels; noncoding RNA; synaptic transmission
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MicroRNAs are short non-coding RNAs that regulate gene expression by targeting complementary sequences in mRNA transcripts, primarily in the 3' untranslated region. They play a role in modulating neural excitability and different processes in the nervous system. Additionally, the expression of microRNAs is regulated by neuronal activity, forming feedback loops.
figure legend MicroRNAs are short non-coding RNAs which negatively regulate gene expression via targeting of complementary sequences, primarily in the 3' untranslated region, of mRNA transcripts. There are hundreds of different microRNAs and each has a target pool which can comprise many different gene transcripts. Many microRNA-target interactions have been identified which can modulate neural excitability, with impacts on processes including synaptic transmission and plasticity, ion transporters and voltage-gated ion channels. The expression of many microRNAs is in turn regulated by neuronal activity, thereby forming feedback loops.
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