4.6 Article

Role of NaV1.9 in inflammatory mediator-induced activation of mouse airway vagal C-fibres

Related references

Note: Only part of the references are listed.
Article Neurosciences

Kv1/D-type potassium channels inhibit the excitability of bronchopulmonary vagal afferent nerves

Hui Sun et al.

Summary: This study demonstrates that the K(v)1/D-type potassium current (I-D) plays a critical role in regulating the activation of bronchopulmonary vagal afferent nerves. The I-D channels stabilize the membrane potential, counterbalance subthreshold depolarization, and promote the adaptation of action potential firings. Down-regulation of I-D channels may contribute to enhanced C-fiber activity in airway diseases.

JOURNAL OF PHYSIOLOGY-LONDON (2022)

Article Neurosciences

NaV1.9 current in muscle afferent neurons is enhanced by substances released during muscle activity

Khrystyna Yu Sukhanova et al.

Summary: During exercise, substances released during muscle contraction activate G-protein-coupled receptors (GPCRs) to increase neuronal activity and generate the exercise pressor reflex (EPR). The enhancement of NaV1.9 channel activity may be a mechanism by which GPCR activation leads to the generation of EPR.

JOURNAL OF NEUROPHYSIOLOGY (2022)

Article Neurosciences

Different sensitivity of action potential generation to the rate of depolarization in vagal afferent A-fiber versus C-fiber neurons

Hui Sun

Summary: This study demonstrates that the action potential discharge in vagal afferent A-fiber neurons is about 20 times more sensitive to the rate of membrane depolarization compared to C-fiber neurons. The sensitivity of action potential generation to the depolarization rate in vagal sensory neurons is independent of the intensity of current stimuli but nearly abrogated by inhibiting the D-type potassium channel. These findings help better understand the mechanisms that control the activation of vagal afferent nerves.

JOURNAL OF NEUROPHYSIOLOGY (2021)

Article Neurosciences

Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons

Stuart B. Mazzone et al.

MOLECULAR NEUROBIOLOGY (2020)

Article Multidisciplinary Sciences

Complementary roles of murine NaV1.7, NaV1.8 and NaV1.9 in acute itch signalling

Helen Kuehn et al.

SCIENTIFIC REPORTS (2020)

Article Neurosciences

Acute activation of bronchopulmonary vagal nociceptors by type I interferons

Mayur J. Patil et al.

JOURNAL OF PHYSIOLOGY-LONDON (2020)

Review Physiology

THE ROLE OF VOLTAGE-GATED SODIUM CHANNELS IN PAIN SIGNALING

David L. Bennett et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Medicine, Research & Experimental

KCNQ/M-channels regulate mouse vagal bronchopulmonary C-fiber excitability and cough sensitivity

Hui Sun et al.

JCI INSIGHT (2019)

Article Medicine, Research & Experimental

A disease mutation reveals a role for NaV1.9 in acute itch

Juan Salvatierra et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Neurosciences

Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin

F. Ru et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

Review Physiology

VAGAL AFFERENT INNERVATION OF THE AIRWAYS IN HEALTH AND DISEASE

Stuart B. Mazzone et al.

PHYSIOLOGICAL REVIEWS (2016)

Article Neurosciences

NaV 1.9: a sodium channel linked to human pain

Sulayman D. Dib-Hajj et al.

NATURE REVIEWS NEUROSCIENCE (2015)

Article Neurosciences

Selective silencing of NaV1.7 decreases excitability and conduction in vagal sensory neurons

Yukiko Muroi et al.

JOURNAL OF PHYSIOLOGY-LONDON (2011)

Article Neurosciences

Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs

Christina Nassenstein et al.

JOURNAL OF PHYSIOLOGY-LONDON (2010)

Article Physiology

P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus

Kevin Kwong et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

Article Neurosciences

Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neurons

B Coste et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2004)

Article Neurosciences

Subtypes of vagal afferent C-fibres in guinea-pig lungs

BJ Undem et al.

JOURNAL OF PHYSIOLOGY-LONDON (2004)