Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 14, Issue 12, Pages 2353-2355Publisher
WILEY-BLACKWELL
DOI: 10.1111/jth.13506
Keywords
ADAMTS-13 protein; human; hemolysis; microangiopathic hemolytic anemia; systemic capillary leak syndrome; thrombocytopenia
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Funding
- NHLBI NIH HHS [R01 HL137991, R56 HL131946] Funding Source: Medline
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Idiopathic systemic capillary leak syndrome (SCLS) is a rare process characterized by acute and recurrent episodes of vascular leakage with severe hypotension, hypoalbuminemia, hemoconcentration and edema. Anemia and thrombocytopenia are not part of this syndrome, but here we present the case of a pediatric patient with a clinical presentation consistent with SCLS who subsequently developed microangiopathic hemolytic anemia at a time when she had significant fluid loss and anasarca. Based on serial ADAMTS-13 levels, we propose that the anemia in this patient developed as a result of ADAMTS-13 loss in the third-space fluid, a novel mechanism for acquired microangiopathic hemolytic anemia.
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