Journal
JOURNAL OF THORACIC ONCOLOGY
Volume 11, Issue 7, Pages 1012-1028Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jtho.2016.04.006
Keywords
Subsolid nodule; Ground -glass nodule; Natural history; Computed tomography; Lung adenocarcinoma
Categories
Funding
- Ministry of Health, Labour and Welfare, Tokyo, Japan [21-5-1]
- Third term Comprehensive Cancer Control Strategy - Ministry of Health, Labour and Welfare, Tokyo, Japan [16-016, 19-1, 22-019]
- National Cancer Center Research and Development Fund, Tokyo, Japan [23-A-25, 23-A-48, 27-A-5]
- Japan Agency for Medical Research and Development (AMED) for the Health and Labor Sciences Research Expenses for Commission [15ck0106096h0002]
- Grants-in-Aid for Scientific Research [24590441] Funding Source: KAKEN
Ask authors/readers for more resources
Introduction: The purpose of this study was to evaluate the natural course of the progression of pulmonary subsolid nodules (SSNs). Materials and Methods: Eight facilities participated in this study. A total of 795 patients with 1229 SSNs were assessed for the frequency of invasive adenocarcinomas. SSNs were classified into three categories: pure ground-glass nodules (PGGNs), heterogeneous GGNs (HGGNs) (solid component detected only in lung windows), and part-solid nodules. Results: The mean prospective follow-up period was 4.3 2.5 years. SSNs were classified at baseline as follows: 1046 PGGNs, 81 HGGNs, and 102 part-solid nodules. Among the 1046 PGGNs, 13 (1.2%) developed into HGGNs and 56 (5.4%) developed into part-solid nodules. Among the 81 HGGNs, 16 (19.8%) developed into part-solid nodules. Thus, the SSNs at the final follow-up were classified as follows: 977 PGGNs, 78 HGGNs, and 174 part-solid nodules. Of the 977 PGGNs, 35 were resected (nine minimally invasive adenocarcinomas [MIAs], 21 adenocarcinomas in situ [AIS], and five atypical adenomatous hyperplasias). Of the 78 HGGNs, seven were resected (five MIAs and two AIS). Of the 174 part-solid nodules, 49 were resected (12 invasive adenocarcinomas, 26 MIAs, 10 AIS, and one adenomatous hyperplasia). For the PGGNs, the mean period until their development into part-solid nodules was 3.8 +/- 2.0 years, whereas the mean period for the HGGNs was 2.1 +/- 2.3 years (p = 0.0004). Conclusion: This study revealed the frequencies and periods of development from PGGNs and HGGNs into part solid nodules. Invasive adenocarcinomas were diagnosed only among the part-solid nodules, corresponding to 1% of all 1229 SSNs. (C) 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available