A mini review of nanomaterials on photodynamic therapy

In this account, the reactive oxygen species (ROS) in photodynamic therapy (PDT) were deliberately reviewed. First, the specific definition of ROS and PDT were readily clarified. Afterward, this review focuses on the fundamental principles and applications of PDT. Due to strong oxidation ability of radicals (e.g., center dot OH and O2 center dot-) and non-radical (e.g., 1O2 and H2O2), these ROS would attack the in vitro and in vivo tumor cells, thus achieving the goal of cancer treatment. Then, ROS in PDT for cancer treatment was thoroughly reviewed, including the mechanism and photosensitizer (PS) selection (i.e., nanomaterials). Ultimately, emphasis was made on the challenges, research gap, and prospects of ROS in cancer treatment and critically discussed. Hopefully, this review can offer detailed theoretical guidance for the researchers who participate in the study regarding ROS in PDT.

Automated summary

This review focuses on the deliberate analysis of reactive oxygen species (ROS) in photodynamic therapy (PDT). It provides specific definitions of ROS and PDT and discusses the fundamental principles and applications of PDT. The strong oxidation ability of radicals and non-radicals in ROS enables them to attack tumor cells and achieve the goal of cancer treatment. Furthermore, the review thoroughly examines the mechanism, photosensitizer (PS) selection, challenges, research gap, and prospects of ROS in cancer treatment.