Lab-on-a-chip systems for cancer biomarker diagnosis

Lab-on-a-chip (LOC) or micro total analysis system is one of the microfluidic technologies defined as the adaptation, miniaturization, integration, and automation of analytical laboratory procedures into a single in-strument or chip. In this article, we review developments over the past five years in the application of LOC biosensors for the detection of different types of cancer. Microfluidics encompasses chemistry and biotechnology skills and has revolutionized healthcare diagnosis. Superior to traditional cell culture or animal models, microfluidic technology has made it possible to reconstruct functional units of organs on chips to study human diseases such as cancer. LOCs have found numerous biomedical applications over the past five years, including integrated bioassays, cell analysis, metabolomics, drug discovery and delivery systems, tissue and organ physi-ology and disease modeling, and personalized medicine. This review provides an overview of the latest de-velopments in microfluidic-based cancer research, with pros, cons, and prospects.

Automated summary

Lab-on-a-chip (LOC) or micro total analysis system is a microfluidic technology that integrates and automates analytical laboratory procedures into a single instrument or chip. This article reviews the recent developments in the application of LOC biosensors for cancer detection. Microfluidics has revolutionized healthcare diagnosis by enabling the reconstruction of functional organ units on chips and studying human diseases like cancer. In the past five years, LOCs have been widely used in various biomedical applications such as bioassays, cell analysis, drug discovery, and personalized medicine. This review provides an overview of microfluidic-based cancer research, including its pros, cons, and future prospects.