Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 88, Issue 4, Pages 2034-2045Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c02257
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A novel, practical, and green synthetic method is reported for the synthesis of various tetrasubstituted allenyl iodides using readily available 1,3-enynes with sulfonyl hydrazides and I2 through tert-butyl hydroperoxide (TBHP)-mediated 1,4sulfonyliodination under metal-free conditions. The proposed method exhibits a broad substrate scope, operational simplicity, tolerance to air, high functional-group tolerance, satisfactory yields, and excellent regioselectivity as well as involves the use of cost-effective reagents such as green oxidants.
Herein, a novel, practical, and green synthetic method using readily available 1,3-enynes with sulfonyl hydrazides and I2 through tert-butyl hydroperoxide (TBHP)-mediated 1,4sulfonyliodination has been developed for synthesizing various tetrasubstituted allenyl iodides under metal-free conditions. Notably, the proposed method exhibits a broad substrate scope, operational simplicity, tolerance to air, high functional-group tolerance, satisfactory yields, and excellent regioselectivity as well as involves the use of cost-effective reagents such as green oxidants.
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