Rapid Total Synthesis of Iheyamine A via a Pictet-Spengler/Redox- Mediated Cyclization Cascade

The Pictet-Spengler reaction between tryptamine and (5-methoxy-2-nitrophenyl)-glyoxal in hot AcOH could trigger a redox-mediated cyclization and reduction sequence to form iheyamine A in 52% yield.

Automated summary

The Pictet-Spengler reaction of tryptamine and (5-methoxy-2-nitrophenyl)-glyoxal in hot AcOH can lead to a redox-mediated cyclization and reduction sequence, resulting in the formation of iheyamine A with a yield of 52%.