Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 88, Issue 7, Pages 4743-4756Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.3c00343
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A mild and efficient coupling method for the reactions of gem-bromonitroalkanes with alpha,alpha-diaryl allyl alcohol trimethylsilyl ethers was reported. The coupling reactions were realized through a cascade involving visible light-induced generation of an alpha-nitroalkyl radical and a subsequent neophyl-type rearrangement. Structurally diverse alpha-aryl-gamma-nitro ketones, especially those bearing a nitrocyclobutyl structure, were prepared in moderate to high yields, which could be converted into spirocyclic nitrones and imines.
A mild and efficient coupling method concerning the reactions of gem-bromonitroalkanes with alpha,alpha-diaryl allyl alcohol trimethylsilyl ethers was reported. A cascade consisting of visible light-induced generation of an alpha-nitroalkyl radical and a subsequent neophyl-type rearrangement was key to realize the coupling reactions. Structurally diverse alpha-aryl-gamma-nitro ketones, especially those bearing a nitrocyclobutyl structure, were prepared in moderate to high yields, which could be converted into spirocyclic nitrones and imines.
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