Rh(III)-Catalyzed [4+1] Annulation of Sulfoximines with Maleimides: Access to Benzoisothiazole Spiropyrrolidinediones

Rh(III)-catalyzed synthesis of benzoisothiazole spiropyrrolidinediones using sulfoximine as a directing group under a C-H activation and [4 + 1] annulation strategy with maleimides as a coupling partner is reported. The cyclization reaction was compatible with various substituted sulfoximine and maleimides. The deuterium-labeling studies were performed to investigate the mechanism of the reaction.

Automated summary

The Rh(III)-catalyzed synthesis of benzoisothiazole spiropyrrolidinediones using sulfoximine as a directing group and maleimides as a coupling partner under a C-H activation and [4 + 1] annulation strategy is described. The cyclization reaction is compatible with various substituted sulfoximine and maleimides. Deuterium-labeling studies were conducted to investigate the mechanism of the reaction.