4.1 Article

Plasma extracellular vesicles and cell-free mitochondrial DNA are associated with cognitive dysfunction in treated older adults with HIV

Journal

JOURNAL OF NEUROVIROLOGY
Volume -, Issue -, Pages -

Publisher

SPRINGER
DOI: 10.1007/s13365-023-01122-6

Keywords

HIV; Aging; Cognition; Inflammation; Frailty; Mitochondria; Extracellular vesicles

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This study explored the association between extracellular vesicles, cell-free mitochondrial DNA, and cognitive dysfunction in older people with HIV. The findings suggest that plasma EVs, urine cf-mtDNA, and 4-meter walk time can predict neurocognitive impairment.
Extracellular vesicles (EVs) are nanoparticles with a role in intercellular communication. Cell-free mitochondrial DNA (cf-mtDNA) has been associated with cognitive dysfunction in people with HIV (PWH). We conducted a nested case-control study to test the hypothesis that plasma EVs are associated with cf-mtDNA and cognitive dysfunction in older PWH. A machine learning-based model identified total EVs, including select EV subpopulations, as well as urine cf-mtDNA and 4-meter walk time carry power to predict the neurocognitive impairment. These features resulted in an AUC-ROC of 0.845 + / - 0.109 (0.615, 1.00).

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