Post-Cardiac Arrest Syndrome

Post-cardiac arrest syndrome (PCAS) is a multi component entity affecting many who survive an initial period of resuscitation following cardiac arrest. This focussed review explores some of the strategies for mitigating the effects of PCAS following the return of spontaneous circulation. We consider the current evidence for controlled oxygenation, strategies for blood pressure targets, the timing of coronary reperfusion, and the evidence for temperature control and treatment of seizures. Despite several large trials investigating specific strategies to improve outcomes after cardiac arrest, many questions remain unanswered. Results of some studies suggest that interventions may benefit specific subgroups of cardiac arrest patients, but the optimal timing and duration of many interventions remain unknown. The role of intracranial pressure monitoring has been the subject of only a few studies, and its benefits remain unclear. Research aimed at improving the management of PCAS is ongoing.

Automated summary

Post-cardiac arrest syndrome (PCAS) is a complex condition that affects survivors of cardiac arrest. This review explores strategies for managing PCAS, including oxygenation, blood pressure control, coronary reperfusion timing, temperature control, and seizure treatment. Despite ongoing research, many questions about the optimal interventions for PCAS remain unanswered, and the role of intracranial pressure monitoring is still unclear.