Journal
JOURNAL OF NEUROLOGY
Volume 270, Issue 7, Pages 3527-3536Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-023-11701-6
Keywords
Developmental disabilites; Premature mortality; Seizures; Multi-morbidity; Antipsychotics prescribing; Neurodevelopment
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This study aimed to measure associations between risk factors for death in people with epilepsy (PWE) and intellectual disabilities (ID). The results showed that people who died had a higher prevalence of genetic conditions, older age, poor physical health, generalized tonic-clonic seizures, polypharmacy (not antiseizure medications) and antipsychotic use. The lack of an epilepsy review in the last 12 months, age over 50, medical condition prevalence, and antipsychotic medication use were identified as associated with increased risk of epilepsy-related death.
BackgroundPeople with epilepsy (PWE) and people with intellectual disabilities (ID) both live shorter lives than the general population and both conditions increase the risk of death further. We aimed to measure associations between certain risk factors for death in PWE and ID.MethodsA retrospective case-control study was conducted in ten regions in England and Wales. Data were collected on PWE registered with secondary care ID and neurology services between 2017 and 2021. Prevalence rates of neurodevelopmental, psychiatric and medical diagnoses, seizure frequency, psychotropic and antiseizure medications (ASM) prescribed, and health activity (epilepsy reviews/risk assessments/care plans/compliance etc.) recorded were compared between the two groups.Results190 PWE and ID who died were compared with 910 living controls. People who died were less likely to have had an epilepsy risk assessment but had a greater prevalence of genetic conditions, older age, poor physical health, generalized tonic-clonic seizures, polypharmacy (not ASMs) and antipsychotic use. The multivariable logistic regression for risk of epilepsy-related death identified that age over 50, medical condition prevalence, antipsychotic medication use and the lack of an epilepsy review in the last 12 months as associated with increased risk of death. Reviews by psychiatrists in ID services was associated with a 72% reduction in the odds of death compared neurology services.ConclusionsPolypharmacy and use of antipsychotics may be associated with death but not ASMs. Greater and closer monitoring by creating capable health communities may reduce the risk of death. ID services maybe more likely to provide this holistic approach.
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