Journal
JOURNAL OF NEURO-ONCOLOGY
Volume 163, Issue 2, Pages 339-344Publisher
SPRINGER
DOI: 10.1007/s11060-023-04342-2
Keywords
Glioblastoma; MIB-1; Ki-67; IDH wild-type
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In this study, the prognostic role of Ki-67/MIB-1-LI in IDHwt GBM patients was retrospectively investigated, and a positive correlation between Ki-67/MIB-1-LI expression < 15% and overall survival was found. This correlation was independent of patient age, Karnofsky performance status scale, extent of surgery, and O6-MeG-DNA methyltransferase promoter methylation status.
PurposeThe Ki-67/MIB-1 labeling index (LI) is clinically used to differentiate between high and low-grade gliomas, while its prognostic value remains questionable. Glioblastoma (GBM) expressing wild-type isocitrate dehydrogenase IDHwt, a relatively common malignant brain tumor in adults, is characterized by a dismal prognosis. Herein, we have retrospectively investigated the prognostic role of Ki-67/MIB-1-LI in a large group of IDHwt GBM.MethodsOne hundred nineteen IDHwt GBM patients treated with surgery followed by Stupp's protocol in our Institution between January 2016 and December 2021 were selected. A cut-off value for Ki-67/MIB-1-LI was used with minimal p-value based approach.ResultsA multivariate analysis showed that Ki-67/MIB-1-LI expression < 15% significantly correlated with a longer overall survival (OS), independently from the age of the patients, Karnofsky performance status scale, extent of surgery and O-6-methylguanine (O6-MeG)-DNA methyltransferase promoter methylation status.ConclusionsAmong other studies focused on Ki-67/MIB-1-LI, this is the first observational study showing a positive correlation between OS of IDHwt GBM patients and Ki-67/MIB-1-LI that we propose as a new predictive marker in this subtype of GBM.
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