Journal
JOURNAL OF NEURAL TRANSMISSION
Volume -, Issue -, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-023-02663-0
Keywords
Montreal Cognitive Assessment; Dystonia; Cognitive screening; Neuropsychology; Movement disorders; Hyperkinetic
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This study aimed to evaluate the clinimetrics of the Montreal Cognitive Assessment (MoCA) in Italian patients with adult-onset idiopathic focal dystonia (AOIFD). The MoCA was administered to 86 AOIFD patients and 92 healthy controls (HCs). The results showed that the MoCA had a reliable structure and was correlated with TMT, BMT, and DAS scores, but not with BDI-II scores. The adjusted MoCA scores accurately detected cognitive impairment and discriminated between patients and HCs. It was also unrelated to disease duration, severity, and motor phenotypes.
This study aimed at assessing the clinimetrics of the Montreal Cognitive Assessment (MoCA) in an Italian cohort of patients with adult-onset idiopathic focal dystonia (AOIFD). N = 86 AOIFD patients and N = 92 healthy controls (HCs) were administered the MoCA. Patients further underwent the Trail-Making Test (TMT) and Babcock Memory Test (BMT), being also screened via the Beck Depression Inventory-II (BDI-II) and the Dimensional Apathy Scale (DAS). Factorial structure and internal consistency were assessed. Construct validity was tested against TMT, BMT, BDI-II and DAS scores, whilst diagnostics against the co-occurrence of a defective performance on at least one TMT measure and on the BMT. Case-control discrimination was examined. The association between MoCA scores and motor-functional measures was explored. The MoCA was underpinned by a mono-component structure and acceptably reliable at an internal level. It converged towards TMT and BMT scores, as well as with the DAS, whilst diverging from the BDI-II. Its adjusted scores accurately detected cognitive impairment (AUC = .86) at a cut-off of < 17.212. The MoCA discriminated patients from HCs (p < .001). Finally, it was unrelated to disease duration and severity, as well as to motor phenotypes. The Italian MoCA is a valid, diagnostically sound and feasible cognitive screener in AOIFD patients.
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