Journal
JOURNAL OF NATURAL PRODUCTS
Volume 86, Issue 4, Pages 672-682Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.2c00580
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Diphyllin (1) and justicidin B (2) are arylnaphthalene lignans with antiviral and antiproliferative effects. Both compounds showed strong inhibition against SARS-CoV-2 and various cancer cell lines. Additional lignans, linadiacin A and B (3 and 4), were isolated and identified from the underground organs of arylnaphthalene lignans. The study also demonstrated the conversion of compound 3 to 2 in acidic media and provided complete structure analysis.
Diphyllin (1) and justicidin B (2) are arylnaphthalene lignans with antiviral and antiproliferative effects. Compound 1 is also known as an effective inhibitor of the Severe evaluate the in vitro antiviral and cytotoxic potency of both lignans in SARS-CoV-2 -infected cells and various cancer cell lines, respectively, 1 and 2 were isolated from the underground organs of arylnaphthalene lignans, denominated linadiacin A and B (3 and 4), were also isolated and identified. In acidic media, 3 was converted by a two-step reaction into 2 via the intermediate 4. Optimum acid treatment conditions were determined to isolate lignans by oneThe results of the conversion, HPLC-tandem mass spectrometry, nuclear magnetic resonance spectroscopy, and molecular modeling studies allowed complete structure analysis. Compounds 1 and 2 were the most effective against SARS-CoV-2 with a 3-log reduction in the viral copy number at a 12.5 mu M concentration. Ten human cancer cell lines showed sensitivity to at least one of the isolated lignans.
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