Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1292, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2023.136063
Keywords
Curcumin; XRD; FTIR; NMR; TG/DTA; Hirshfeld surfaces
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Two important curcumin derivatives were synthesized and characterized for their chemical and physical properties. The compounds exhibited promising crystalline structure, optical properties, and potent antibacterial activity.
Two chemically and biologically important curcumin derivatives, namely (3E, 5E)-3, 5- bis (3-ethoxy-4-methoxybenzylidene)-1-methylpiperidine-4-one and (3E, 5E) -3, 5-bis (2, 4 -dimethoxybenzylidine) -1-methylpiperidine - 4 - one was synthesised from the mixture of 3-ethoxy-4-methoxybenzaldehyde and 1-methyl piperidone (EMPM) and 2,4-dimethoxybenzaldehyde with 1-methyl piperidone (MBMP). The resultant compounds were chemically characterised using X-ray techniques. Both the compounds were crystallised in a triclinic crystal system with space group P-(1) over bar and their 3D structures were stabilised by the weak C-H center dot center dot center dot O, C-H center dot center dot center dot pi, and pi center dot center dot center dot pi intermolecular interactions. The title materials were also analysed for their optical properties via NMR, UV-vis, FTIR, and PL spectra. TG and DTA thermograms of the compounds were investigated to derive melting points, thermal stability, and other associated thermal processes. Information about short contacts such as C-H center dot center dot center dot pi, and pi center dot center dot center dot pi molecular interactions was studied using Hirshfeld surfaces analysis. In vitro screening of the compounds has been performed for their antibacterial activity, which discloses their highly promising anti-bacterial properties against the tested microorganisms.
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