☆ 4.7 Article

Transcriptional changes in multiple endocrine organs from lethal cases of COVID-19

JOURNAL OF MOLECULAR MEDICINE-JMM (2023)

Related references

Note: Only part of the references are listed.

Article Medicine, General & Internal

Estradiol and Dihydrotestosterone Levels in COVID-19 Patients

Taleen A. MacArthur et al.

Summary: This study investigated the differences in plasma sex hormone levels between male and female COVID-19 patients and healthy volunteers. The results showed that there are sex-specific patterns of hypogonadism in males and females, which may be associated with disease development and severity.

MAYO CLINIC PROCEEDINGS (2023)

Add to Collection

Review Microbiology

SARS-CoV-2 variant biology: immune escape, transmission and fitness

Alessandro G. Carabelli et al.

Summary: The emergence of the SARS-CoV-2 variants of concern (VOCs) in late 2020 marked a major change in the virus's adaptation to humans, resulting in increased transmission rates and ability to evade immune responses. These VOCs, designated Alpha, Beta, Gamma, Delta, and Omicron, rapidly became dominant globally, outcompeting previous variants. The success of VOCs can be attributed to the altered properties of the virus and changes in antigenicity, influenced by both vaccination and prior infection.

NATURE REVIEWS MICROBIOLOGY (2023)

Add to Collection

Review Endocrinology & Metabolism

COVID-19 as a Trigger for Type 1 Diabetes

Yichen Wang et al.

Summary: Type 1 diabetes is caused by immune-mediated destruction of islet beta cells, and viruses, including SARS-CoV-2, may trigger or unmask T1D. The mechanisms of beta-cell damage include virus-triggered cell death, immune-mediated loss of pancreatic beta cells, and damage to beta cells due to infection of surrounding cells. Further studies are needed to investigate the long-term outcomes and determine the causal relationship between SARS-CoV-2 and T1D.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2023)

Add to Collection

Review Multidisciplinary Sciences

Human genetic and immunological determinants of critical COVID-19 pneumonia

Qian Zhang et al.

Summary: SARS-CoV-2 infection is generally mild, but in around 10% of cases, it can lead to severe pneumonia and potentially death. Genetic factors, such as inborn errors of type I interferons, and pre-existing auto-antibodies can increase the risk of critical illness. The production of type I interferons is essential for host defense against the virus.

NATURE (2022)

Add to Collection

Article Cell Biology

Limited extent and consequences of pancreatic SARS-CoV-2 infection

Verena van der Heide et al.

Summary: In this study, comprehensive single-cell analysis of SARS-CoV-2-infected human pancreatic islets revealed that the infection is strictly dependent on the ACE2 receptor and targets various pancreatic cell types. However, the infection is limited and non-cytopathic, causing only mild cellular perturbations and inflammatory responses. Similar outcomes were observed with endemic coronaviruses. Further evaluation is needed to determine if COVID-19-induced damage to the pancreas and immunological changes increase the risk of diabetes.

CELL REPORTS (2022)

Add to Collection

Article Endocrinology & Metabolism

Adipose tissue in COVID-19: detection of SARS-CoV-2 in adipocytes and activation of the interferon-alpha response

A. Basolo et al.

Summary: In fatal cases of COVID-19, a significant proportion of adipocytes have been found to contain the SARS-CoV-2 nucleocapsid antigen, indicating direct infection of subcutaneous fat cells by the virus. Infection seems to activate the IFN alpha pathway and attract infiltrating leukocytes. Due to the large numbers of adipocytes in adults, adipose tissue serves as a significant reservoir for SARS-CoV-2 and an important source of inflammatory mediators.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2022)

Add to Collection

Letter Endocrinology & Metabolism

COVID-19 targets human adrenal glands

Waldemar Kanczkowski et al.

LANCET DIABETES & ENDOCRINOLOGY (2022)

Add to Collection

Article Endocrinology & Metabolism

The Association Between COVID-19 and Thyroxine Levels: A Meta-Analysis

Yiru Chen et al.

Summary: There is an association between abnormal thyroid-related hormones in COVID-19 patients and the severity of the disease and mortality.

FRONTIERS IN ENDOCRINOLOGY (2022)

Add to Collection

Article Endocrinology & Metabolism

Suppression of Pituitary Hormone Genes in Subjects Who Died From COVID-19 Independently of Virus Detection in the Gland

Anello Marcello Poma et al.

Summary: This study found that the pituitary glands of lethal cases of COVID-19 had the SARS-CoV-2 genome and antigens, confirming viral infection in the pituitary gland. Activation of type I interferon signaling and increased levels of neutrophil and cytotoxic cell scores were observed in virus-positive glands, while mRNA transcripts of pituitary hormones and pituitary developmental/regulatory genes were suppressed in all COVID-19 cases.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Add to Collection

Article Multidisciplinary Sciences

Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19

Tanja Paul et al.

Summary: This study reveals the tropism of SARS-CoV-2 to adrenal glands, leading to adrenalitis and severe damage. This can impact immune regulation and adrenal function, highlighting the importance of monitoring adrenal function in the treatment and recovery of COVID-19.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Endocrinology & Metabolism

COVID-19 autopsy cases: detection of virus in endocrine tissues

A. M. Poma et al.

Summary: The study found that the SARS-CoV-2 virus can spread to endocrine organs in severe cases of COVID-19, with evidence of virus presence in abdominal subcutaneous adipose tissue, testes, and thyroid samples; Further research is needed to assess the occurrence rate of this phenomenon in clinically mild cases; Potential long-term effects of COVID-19 on endocrine functions should be taken into consideration.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2022)

Add to Collection

Review Endocrinology & Metabolism

Adrenal Gland Function and Dysfunction During COVID-19

Waldemar Kanczkowski et al.

Summary: COVID-19 is a major health concern worldwide with a possible association with adrenal dysfunction. While widespread cellular damage is not observed, some patients may develop corticosteroid insufficiency. During COVID-19, some patients may experience adrenal insufficiency due to disease progression or prolonged use of synthetic hormones.

HORMONE AND METABOLIC RESEARCH (2022)

Add to Collection

Article Endocrinology & Metabolism

Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results From the DiViD Study

Lars Krogvold et al.

Summary: The study reveals that newly diagnosed type 1 diabetes patients have enhanced gene expressions related to cellular stress and increased immunological activity in their islet cells compared to controls. Additionally, increased viral response proteins were observed in beta-cells of newly diagnosed type 1 diabetes patients, providing evidence for the hypothesis that enteroviral infection of islet beta-cells contributes to the pathogenesis of type 1 diabetes.

FRONTIERS IN ENDOCRINOLOGY (2022)

Add to Collection

Review Immunology

MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention

Bo Zhong et al.

Summary: MITA is an ER-associated protein that senses cyclic dinucleotide and induces type-I interferons and innate immune responses. Recent studies have shown that MITA has evolutionary conserved functions in sensing cyclic dinucleotide and inducing autophagy. MITA-mediated signaling is associated with autoimmune disorders in humans.

CURRENT OPINION IN IMMUNOLOGY (2022)

Add to Collection

Article Endocrinology & Metabolism

Autopsy Study of Testicles in COVID-19: Upregulation of Immune-Related Genes and Downregulation of Testis-Specific Genes

Alessio Basolo et al.

Summary: Infection by SARS-CoV-2 may lead to testicular dysfunction and affect male fertility. Testicular cells are commonly infected in lethal COVID-19 cases, which is associated with activation of interferon pathways and downregulation of testis-specific genes involved in spermatogenesis.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Add to Collection

Letter Endocrinology & Metabolism

Response to Letter to the Editor From Nelson et al: Understanding the Link Between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response

Andrea S. Foulkes et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Add to Collection

Article Cell Biology

SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages

Giovanny J. Martinez-Colon et al.

Summary: This study found that adipocytes in COVID-19 autopsy cases were infected by SARS-CoV-2, accompanied by inflammatory infiltrate. The study also revealed that SARS-CoV-2 infected adipose tissue-resident macrophages and initiated inflammatory responses. These findings suggest that SARS-CoV-2 infection in adipose tissue could contribute to the severity of COVID-19 through viral replication and induction of inflammation.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Add to Collection

Article Pharmacology & Pharmacy

Physiological regulation of leptin as an integrative signal of reproductive readiness

Maggie C. Evans et al.

Summary: This review discusses the different mechanisms by which leptin, as a crucial factor, integrates and relays information about metabolic, psychological, environmental, and immune conditions to the central neuronal network that governs reproductive function.

CURRENT OPINION IN PHARMACOLOGY (2022)

Add to Collection

Article Immunology

Potential Influence of Menstrual Status and Sex Hormones on Female Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Cross-sectional Multicenter Study in Wuhan, China

Ting Ding et al.

Summary: Recent studies have shown that female COVID-19 patients have lower morbidity, severe case rate, and mortality compared to males. Nonmenopausal female patients had milder severity and better outcome, while menopausal patients had longer hospitalization times. Anti-Mullerian hormone (AMH) and estradiol (E2) were negatively correlated with COVID-19 severity, with E2 regulating cytokines related to immunity and inflammation.

CLINICAL INFECTIOUS DISEASES (2021)

Add to Collection

Article Obstetrics & Gynecology

Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age

Kezhen Li et al.

Summary: While COVID-19 infection may affect menstrual volume and cycle length in women of child-bearing age, the average levels of sex hormones and ovarian reserve did not show significant changes. The changes observed in menstruation may be temporary and reversible, potentially attributed to transient suppression of ovarian function.

REPRODUCTIVE BIOMEDICINE ONLINE (2021)

Add to Collection

Article Cell Biology

Leptin correlates with monocytes activation and severe condition in COVID-19 patients

Jingya Wang et al.

Summary: Leptin, a cytokine found in significantly altered profiles in severe COVID-19 patients, correlates with disease severity and may exacerbate or dysregulate immune responses through activating monocytes. This study suggests a possible mechanism by which overweight COVID-19 patients have a greater tendency to develop severe conditions, providing insights into potential therapeutic strategies.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Add to Collection

Article Virology

Zika Virus Infection in the Ovary Induces a Continuously Elevated Progesterone Level and Compromises Conception in Interferon Alpha/Beta Receptor-Deficient Mice

Yingying Zhang et al.

JOURNAL OF VIROLOGY (2021)

Add to Collection

Review Immunology

Dual Nature of Type I Interferons in SARS-CoV-2-Induced Inflammation

Cecile King et al.

Summary: Inhibition of IFN-I by SARS-CoV-2 can worsen the disease and affect the immune response, but therapeutic boosting of IFN-I has a narrow time window for efficacy. Further research is needed to explore therapeutic approaches and vaccine design to counteract this limitation.

TRENDS IN IMMUNOLOGY (2021)

Add to Collection

Article Cell Biology

SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

Chien-Ting Wu et al.

Summary: There is evidence suggesting a complex relationship between COVID-19 and diabetes, with SARS-CoV-2 being able to directly induce beta cell killing and this effect being rescued by NRP1 inhibition.

CELL METABOLISM (2021)

Add to Collection

Article Multidisciplinary Sciences

High-dimensional characterization of post-acute sequelae of COVID-19

Ziyad Al-Aly et al.

Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.

NATURE (2021)

Add to Collection

Article Cell Biology

Physiological and pathological functions of βB2-crystallins in multiple organs: a systematic review

Meihui Li et al.

Aging-US (2021)

Add to Collection

Article Cell Biology

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2

Moritz Reiterer et al.

Summary: The study found that hyperglycemia is common among patients with ARDS, and in patients with both ARDS and COVID-19, insulin resistance is the main cause of hyperglycemia. COVID-19 patients have lower levels of adiponectin, and SARS-CoV-2 may infect adipocytes, leading to dysfunction of adipose tissue.

CELL METABOLISM (2021)

Add to Collection

Article Cell Biology

Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin

Rodolfo Soria-Castro et al.

Summary: The immune response plays a crucial role in SARS-CoV-2 infection, with mast cells potentially being important players in the inflammatory response. Levels of CPA3 and serotonin may serve as relevant biomarkers in COVID-19 patients.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Add to Collection

Article Endocrinology & Metabolism

Activation of Type I and Type II Interferon Signaling in SARS-CoV-2-Positive Thyroid Tissue of Patients Dying from COVID-19

Anello Marcello Poma et al.

Summary: COVID-19 can directly infect the thyroid gland, leading to immune response activation and potential thyroid dysfunction.

THYROID (2021)

Add to Collection

Review Immunology

Decoding the dynamics of multilayered stochastic antiviral IFN-I responses

Laura C. Van Eyndhoven et al.

Summary: Type I Interferon (IFN-I) plays important roles in antiviral immunity and has various immunomodulatory functions. Despite the highly heterogeneous cellular decisions within the IFN-I system, they are tightly regulated. Innovative single-cell technologies and mathematical models are needed to reveal this complexity.

TRENDS IN IMMUNOLOGY (2021)

Add to Collection

Article Cell Biology

Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients

Dickson W. L. Wong et al.

Summary: The SARS-CoV-2 virus has been shown to have a multiorgan tropism, primarily infecting epithelial cells across various organs, and co-localizing with ACE2 and TMPRSS2. However, apart from the respiratory tract, there were no specific histomorphologic alterations attributed to SARS-CoV-2 infection in other organs.

CELLS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The Influence of Oxidative Stress on Thyroid Diseases

Joanna Kochman et al.

Summary: Thyroid diseases are increasingly associated with oxidative stress, and the oxidative profile can be used to evaluate patients' conditions. Oxidative stress appears to play a significant role in the development of thyroid dysfunction and diseases.

ANTIOXIDANTS (2021)

Add to Collection

Article Endocrinology & Metabolism

Thyroid Function Before, During, and After COVID-19

Bernard Khoo et al.

Summary: Most patients with COVID-19 present with euthyroidism. Mild reductions in TSH and FT4 were observed in COVID-19 patients, consistent with a nonthyroidal illness syndrome. In survivors of COVID-19, thyroid function tests at follow-up returned to baseline.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Add to Collection

Article Endocrinology & Metabolism

Thyrotoxicosis in patients with COVID-19: the THYRCOV study

Andrea Lania et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2020)

Add to Collection

Article Reproductive Biology

Interferon tau-dependent and independent effects of the bovine conceptus on the endometrial transcriptome

Daniel J. Mathew et al.

BIOLOGY OF REPRODUCTION (2019)

Add to Collection

Review Endocrinology & Metabolism

Clinical perspectives in congenital adrenal hyperplasia due to 3-hydroxysteroid dehydrogenase type 2 deficiency

Abdullah M. Al Alawi et al.

ENDOCRINE (2019)

Add to Collection

Review Endocrinology & Metabolism

The somatostatin-secreting pancreatic δ-cell in health and disease

Patrik Rorsman et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Add to Collection

Review Rheumatology

Leptin in the interplay of inflammation, metabolism and immune system disorders

Vanessa Abella et al.

NATURE REVIEWS RHEUMATOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Clinical, genetic, and structural basis of congenital adrenal hyperplasia due to 11β-hydroxylase deficiency

Ahmed Khattab et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection

Review Immunology

Translation inhibition and stress granules in the antiviral immune response

Craig McCormick et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Add to Collection

Review Immunology

Immune regulation by glucocorticoids

Derek W. Cain et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Add to Collection

Article Mathematical & Computational Biology

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

Andrew D. Rouillard et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein

Tobias Karlberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Add to Collection

Review Endocrinology & Metabolism

Thyroid transcription factors in development, differentiation and disease

Lara P. Fernandez et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Structures of Human Steroidogenic Cytochrome P450 17A1 with Substrates

Elyse M. Petrunak et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Add to Collection

Article Food Science & Technology

Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules

Amelie Berton et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2009)

Add to Collection

© Peeref 2019-2024. All rights reserved.