Role and therapeutic potential of gelsolin in atherosclerosis

Atherosclerosis is the major pathophysiological basis of a variety of cardiovascular diseases and has been recognized as a lipid-driven chronic inflammatory disease. Gelsolin (GSN) is a member of the GSN family. The main function of GSN is to cut and seal actin filaments to regulate the cytoskeleton and participate in a variety of biological functions, such as cell movement, morphological changes, metabolism, apoptosis and phagocytosis. Recently, more and more evidences have demonstrated that GSN is Closely related to atherosclerosis, involving lipid metabolism, inflammation, cell proliferation, migration and thrombosis. This article reviews the role of GSN in atherosclerosis from inflammation, apoptosis, angiogenesis and thrombosis.

Automated summary

Atherosclerosis is a lipid-driven chronic inflammatory disease and the major pathophysiological basis of various cardiovascular diseases. Gelsolin, a member of the Gelsolin family, plays a crucial role in regulating the cytoskeleton and participating in biological functions such as cell movement, metabolism, apoptosis, and phagocytosis. Increasing evidence suggests that Gelsolin is closely related to atherosclerosis, involving lipid metabolism, inflammation, cell proliferation, migration, and thrombosis. This article reviews the role of Gelsolin in atherosclerosis from the perspectives of inflammation, apoptosis, angiogenesis, and thrombosis.