Related references
Note: Only part of the references are listed.Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity
Cerise Yuen-Ki Chan et al.
HEPATOLOGY (2023)
Discovery of CZS-241: A Potent, Selective, and Orally Available Polo-Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia
Yin Sun et al.
JOURNAL OF MEDICINAL CHEMISTRY (2023)
The cell cycle-related genes RHAMM, AURKA, TPX2, PLK1, and PLK4 are associated with the poor prognosis of breast cancer patients
Iris Kahl et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2022)
Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies
Xufen Yu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Strategies for designing proteolysis targeting chimaeras (PROTACs)
Shipeng He et al.
MEDICINAL RESEARCH REVIEWS (2022)
Novel CRBN-Recruiting Proteolysis-Targeting Chimeras asDegraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy
Jin Liu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence
Chandra K. Singh et al.
PROSTATE (2022)
Structure-based discovery of 1-(3-fluoro-5-(5-(3-(methylsulfonyl) phenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl)-3-(pyrimidin-5-yl)urea as a potent and selective nanomolar type-II PLK4 inhibitor
Yin Sun et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation
Donghuan Sun et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
Discovery of a Potent and Selective Degrader for USP7
Yuan Pei et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)
Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d] pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer
Yin Sun et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study
Yin Sun et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Chemistries of bifunctional PROTAC degraders
Chaoguo Cao et al.
CHEMICAL SOCIETY REVIEWS (2022)
PROTACs: past, present and future
Ke Li et al.
CHEMICAL SOCIETY REVIEWS (2022)
Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis
Chang-Hyeon Kim et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2022)
Targeting Polo-like Kinase 4 Triggers Polyploidy and Apoptotic Cell Death in TP53-Mutant Acute Myeloid Leukemia
Edward Ayoub et al.
BLOOD (2021)
Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy
Ruijuan Du et al.
MOLECULAR CANCER (2021)
Polo-Like Kinase 4's Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy
Xiaoyang Zhang et al.
FRONTIERS IN ONCOLOGY (2021)
Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment
Oana-Maria Thoma et al.
FRONTIERS IN PHARMACOLOGY (2021)
Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs
Robert P. Law et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Future prospects for mitosis-targeted antitumor therapies
Alfonso Serrano-del Valle et al.
BIOCHEMICAL PHARMACOLOGY (2021)
Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK)
Shaowen Xie et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer
Xin Han et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
PROTAC Technology: Opportunities and Challenges
Hongying Gao et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
MiR-654-3p Suppresses Non-Small Cell Lung Cancer Tumourigenesis by Inhibiting PLK4
Jiang-tao Pu et al.
ONCOTARGETS AND THERAPY (2020)
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer
Zhong Y. Yeow et al.
NATURE (2020)
TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
Franz Meitinger et al.
NATURE (2020)
Cfi-400945 Induces Cytokinesis Failure By Activating Hippo Signaling Pathway in Diffuse Large B-Cell Lymphoma
Yi Zhao et al.
BLOOD (2020)
Polo-like kinases and acute leukemia
Oksana Goroshchuk et al.
ONCOGENE (2019)
PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma
Zuoxin Zhang et al.
CANCER LETTERS (2019)
Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer
Amreena Suri et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
PLK4: a promising target for cancer therapy
Yi Zhao et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)
High PLK4 expression promotes tumor progression and induces epithelial-mesenchymal transition by regulating the Wnt/-catenin signaling pathway in colorectal cancer
Zhibin Liao et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2019)
PLK4: a link between centriole biogenesis and cancer
Radhika Radha Maniswami et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2018)
Polo-like kinase 4 mediates epithelial-mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway
Xiangdong Tian et al.
CELL DEATH & DISEASE (2018)
CFI-400945 is not a selective cellular PLK4 inhibitor
Karen Oegema et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect
Qian Lei et al.
CELL DEATH & DISEASE (2018)
Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts
I. Lohse et al.
ONCOTARGET (2017)
Synthesis and biological evaluation of (E)-4-(3-arylvinyl-1H-indazol-6-yl) pyrimidin-2-amine derivatives as PLK4 inhibitors for the treatment of breast cancer
Zhihao Liu et al.
RSC ADVANCES (2017)
Reversible centriole depletion with an inhibitor of Polo-like kinase 4
Yao Liang Wong et al.
SCIENCE (2015)
The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent
Peter B. Sampson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer
Kazuya Shinmura et al.
MOLECULAR BIOLOGY REPORTS (2014)
Polo-like kinases: structural variations lead to multiple functions
Sihem Zitouni et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein
Martin Fischer et al.
NUCLEIC ACIDS RESEARCH (2014)
Polo-like Kinase 4 Shapes Up
Michelle S. Levine et al.
STRUCTURE (2014)
Polo Boxes Come out of the Crypt: A New View of PLK Function and Evolution
Swadhin Chandra Jana et al.
STRUCTURE (2012)
The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication
Anja Puklowski et al.
NATURE CELL BIOLOGY (2011)