4.7 Article

Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases

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Tetrahydroxanthones from Mongolian medicinal plant Gentianella amarella ssp acuta

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JOURNAL OF NATURAL MEDICINES (2016)

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Selective inhibition of the kinase DYRK1A by targeting its folding process

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NATURE COMMUNICATIONS (2016)

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Harmine stimulates proliferation of human neural progenitors

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PEERJ (2016)

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Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis

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BIOORGANIC & MEDICINAL CHEMISTRY (2015)

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Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

10-lodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A

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JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Physical

The n -> pi* interaction: a rapidly emerging non-covalent interaction

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PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2015)

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Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

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NATURE COMMUNICATIONS (2015)

Article Food Science & Technology

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

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MOLECULAR NUTRITION & FOOD RESEARCH (2014)

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Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II

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MOLECULES (2014)

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Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I

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MOLECULES (2014)

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Identification of a Novel Function of CX-4945 as a Splicing Regulator

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PLOS ONE (2014)

Article Chemistry, Medicinal

Development of DANDYs, New 3,5-Diaryl-7-azaindoles Demonstrating Potent DYRK1A Kinase Inhibitory Activity

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JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A

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MOLECULES (2013)

Article Toxicology

Computer-aided identification of novel protein targets of bisphenol A

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TOXICOLOGY LETTERS (2013)

Article Plant Sciences

Library-based Discovery of DYRK1A/CLK1 Inhibitors from Natural Product Extracts

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PLANTA MEDICA (2012)

Review Clinical Neurology

Developments in harmine pharmacology - Implications for ayahuasca use and drug-dependence treatment

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PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2012)

Article Cell & Tissue Engineering

Wnt Signaling Orchestration with a Small Molecule DYRK Inhibitor Provides Long-Term Xeno-Free Human Pluripotent Cell Expansion

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STEM CELLS TRANSLATIONAL MEDICINE (2012)

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Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)

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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)

Article Biochemistry & Molecular Biology

Synthesis and evaluation of beta-carboline derivatives as potential monoamine oxidase inhibitors

J. Reniers et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

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CHEMISTRY & BIOLOGY (2011)

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Structural basis of CX-4945 binding to human protein kinase CK2

Andrew D. Ferguson et al.

FEBS LETTERS (2011)

Article Chemistry, Medicinal

Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Rapid-Response Splicing Reporter Screens Identify Differential Regulators of Constitutive and Alternative Splicing

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MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Multidisciplinary Sciences

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

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NATURE COMMUNICATIONS (2010)

Article Biochemistry & Molecular Biology

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

Nora Goeckler et al.

FEBS JOURNAL (2009)

Article Plant Sciences

Dihydrostilbene Derivatives from the Mongolian Medicinal Plant Scorzonera radiata

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JOURNAL OF NATURAL PRODUCTS (2009)

Article Multidisciplinary Sciences

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

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PLOS ONE (2009)

Article Biochemistry & Molecular Biology

DYRK3 Dual-specificity Kinase Attenuates Erythropoiesis during Anemia

Olga Bogacheva et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Structure of human monoamine oxidase A at 2.2-Å resolution:: The control of opening the entry for substrates/inhibitors

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Toxicology

c-Jun N-Terminal Kinase Signaling Inhibitors Under Development

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TOXICOLOGICAL RESEARCH (2008)

Article Biochemistry & Molecular Biology

The selectivity of protein kinase inhibitors: a further update

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BIOCHEMICAL JOURNAL (2007)

Article Biochemistry & Molecular Biology

DYRK1A-mediated hyperphosphorylation of Tau - A functional link between Down syndrome and Alzheimer disease

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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Meeting Abstract Hematology

GSK626616: A DYRK3 inhibitor as a potential new therapy for the treatment of anemia

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BLOOD (2007)

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Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110α inhibitors

Masahiko Hayakawa et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives

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PHYTOCHEMISTRY (2006)

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A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling

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Article Biochemical Research Methods

A comparison of assay performance measures in screening assays:: Signal window, Z′ factor, and assay variability ratio

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JOURNAL OF BIOMOLECULAR SCREENING (2006)

Article Biochemistry & Molecular Biology

A pharmacological map of the PI3-K family defines a role for p110 alpha in insulin signaling

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Article Chemistry, Organic

Microwave-mediated solventless synthesis of new derivatives of marine alkaloid Leucettamine B

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TETRAHEDRON LETTERS (2002)

Article Plant Sciences

A new bioactive triene aldehyde from the marine sponge Leucetta microraphis

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