☆ 4.5 Editorial Material

MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1

JOURNAL OF MEDICAL GENETICS (2023)

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30 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes

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Summary: This study highlights the importance of cancer predisposition gene testing conducted in the Manchester Centre for Genomic Medicine over the past 30 years. The data shows that a significant number of index cases with germline gene variants can be identified through diagnostic screening tests, leading to subsequent cascade testing, which is essential for service provision and health economic assessment.

EUROPEAN JOURNAL OF HUMAN GENETICS (2022)

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