Multiparametric Magnetic Resonance Investigations on Acute and Long-Term Kidney Injury

Acute kidney injury (AKI) is a frequent complication of critical illness and carries a significant risk of short- and long-term mortality. The prediction of the progression of AKI to long-term injury has been difficult for renal disease treatment. Radiologists are keen for the early detection of transition from AKI to long-term kidney injury, which would help in the preventive measures. The lack of established methods for early detection of long-term kidney injury underscores the pressing needs of advanced imaging technology that reveals microscopic tissue alterations during the progression of AKI. Fueled by recent advances in data acquisition and post-processing methods of magnetic resonance imaging (MRI), multiparametric MRI is showing great potential as a diagnostic tool for many kidney diseases. Multiparametric MRI studies offer a precious opportunity for real-time noninvasive monitoring of pathological development and progression of AKI to long-term injury. It provides insight into renal vasculature and function (arterial spin labeling, intravoxel incoherent motion), tissue oxygenation (blood oxygen level-dependent), tissue injury and fibrosis (diffusion tensor imaging, diffusion kurtosis imaging, T1 and T2 mapping, quantitative susceptibility mapping). The multiparametric MRI approach is highly promising but the longitudinal investigation on the transition of AKI to irreversible long-term impairment is largely ignored. Further optimization and implementation of renal MR methods in clinical practice will enhance our comprehension of not only AKI but chronic kidney diseases. Novel imaging biomarkers for microscopic renal tissue alterations could be discovered and benefit the preventative interventions. This review explores recent MRI applications on acute and long-term kidney injury while addressing lingering challenges, with emphasis on the potential value of the development of multiparametric MRI for renal imaging on clinical systems. Evidence Level1 Technical EfficacyStage 2

Automated summary

Acute kidney injury (AKI) is a common complication of critical illness, with significant short- and long-term mortality risks. Early detection of the transition from AKI to long-term kidney injury is important for preventive measures, but current methods are lacking. Multiparametric magnetic resonance imaging (MRI) shows promise as a noninvasive diagnostic tool for monitoring the progression of AKI to long-term injury. It provides valuable information on renal vasculature, tissue oxygenation, and injury/fibrosis. However, research on the transition of AKI to irreversible long-term impairment is limited. Further optimization and implementation of renal MRI methods could improve our understanding of AKI and chronic kidney diseases and lead to the discovery of new imaging biomarkers. This review discusses recent MRI applications for acute and long-term kidney injury and highlights the potential value of multiparametric MRI in clinical practice.