Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 58, Issue 1, Pages 44-60Publisher
WILEY
DOI: 10.1002/jmri.28689
Keywords
quantitative mapping; accelerated relaxometry; compressed sensing; deep learning; magnetic resonance fingerprinting
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Osteoarthritis (OA) is a degenerative joint disease that causes significant burdens to society. Compositional MRI is a quantitative imaging technique that can provide valuable information about cartilage changes in early OA, serving as early imaging biomarkers for objective evaluation. This review summarizes current and emerging techniques for cartilage compositional MRI, including MR fingerprinting, compressed sensing, multiexponential relaxometry, improved pulse sequences, and deep learning-based methods.
Osteoarthritis (OA) is a widely occurring degenerative joint disease that is severely debilitating and causes significant socioeconomic burdens to society. Magnetic resonance imaging (MRI) is the preferred imaging modality for the morphological evaluation of cartilage due to its excellent soft tissue contrast and high spatial resolution. However, its utilization typically involves subjective qualitative assessment of cartilage. Compositional MRI, which refers to the quantitative characterization of cartilage using a variety of MRI methods, can provide important information regarding underlying compositional and ultrastructural changes that occur during early OA. Cartilage compositional MRI could serve as early imaging biomarkers for the objective evaluation of cartilage and help drive diagnostics, disease characterization, and response to novel therapies. This review will summarize current and ongoing state-of-the-art cartilage compositional MRI techniques and highlight emerging methods for cartilage compositional MRI including MR fingerprinting, compressed sensing, multiexponential relaxometry, improved and robust radio-frequency pulse sequences, and deep learning-based acquisition, reconstruction, and segmentation. The review will also briefly discuss the current challenges and future directions for adopting these emerging cartilage compositional MRI techniques for use in clinical practice and translational OA research studies. Evidence Level2 Technical EfficacyStage 2.
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