Authors reply: Low vitamin D is a marker for poor health and increased risk for disease - but causality is still unclear in most cases

Editorial Material Medicine, General & Internal

Low vitamin D is a marker for poor health and increased risk for disease: But causality is still unclear in most cases

Peter Bergman

JOURNAL OF INTERNAL MEDICINE (2023)

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News Item Medicine, General & Internal

And now cod liver oil

H. Vaillant et al.

EXERCER-LA REVUE FRANCOPHONE DE MEDECINE GENERALE (2023)

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Article Immunology

Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells

Daniel Chauss et al.

Summary: Research suggests that Vitamin D plays a crucial role in regulating the transcriptional response of T cells, leading to the transition from pro-inflammatory to suppressive cells. In patients with severe COVID-19, disruptions in Vitamin D signaling may be responsible for dysregulation of the immune system, resulting in increased inflammation.

NATURE IMMUNOLOGY (2022)

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Article Medicine, General & Internal

Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT)

David A. Jolliffe et al.

Summary: The population level implementation of a test-and-treat approach to vitamin D supplementation did not reduce the risk of acute respiratory tract infection and COVID-19 among individuals with suboptimal vitamin D status.

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Article Medicine, General & Internal

Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial

Sonja H. Brunvoll et al.

Summary: A randomized controlled trial in Norway found that daily supplementation with low-dose cod liver oil in winter did not reduce the risk of SARS-CoV-2 infection, serious covid-19, or other acute respiratory infections in adults.

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Article Food Science & Technology

Vitamin D Rescues Pancreatic β Cell Dysfunction due to Iron Overload via Elevation of the Vitamin D Receptor and Maintenance of Ca2+ Homeostasis

Yoo Jeong Lee et al.

Summary: This study investigates the influence of iron and vitamin D on pancreatic beta cell functions and reveals that iron overload reduces VDR levels in beta cells while vitamin D can rescue beta cell dysfunction caused by iron accumulation. The findings suggest an inverse relationship between iron and vitamin D in regulating pancreatic beta cell function.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Article Endocrinology & Metabolism

Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

David A. Jolliffe et al.

Summary: Vitamin D supplementation was found to be safe and reduce the risk of acute respiratory infections, especially when administered in daily doses of 400-1000 IU for up to 12 months and to participants aged 1.00-15.99 years. However, the relevance of these findings to COVID-19 is uncertain and further investigation is needed.

LANCET DIABETES & ENDOCRINOLOGY (2021)

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Review Medicine, General & Internal