The Type VI Secretion System Contributes to the Invasiveness of Liver Abscess Caused by Klebsiella pneumoniae

Review Immunology

Innate Host Defense against Klebsiella pneumoniae and the Outlook for Development of Immunotherapies

Clement Opoku-Temeng et al.

Summary: The article discusses the characteristics of Klebsiella pneumoniae and its impact on host defense, as well as the challenges of treatment caused by antibiotic resistance and limited treatment options.

JOURNAL OF INNATE IMMUNITY (2022)

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Article Immunology

Distribution of type VI secretion system (T6SS) in clinical Klebsiella pneumoniae strains from a Chinese hospital and its potential relationship with virulence and drug resistance

Wenjian Liao et al.

Summary: This study characterized the type VI secretion system (T6SS) in 248 Klebsiella pneumoniae isolates from a Chinese hospital and found a high prevalence of T6SS genes. T6SS-positive isolates showed higher drug resistance and biofilm formation ability, as well as a higher frequency of virulence genes.

MICROBIAL PATHOGENESIS (2022)

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Article Microbiology

Identification and Comparative Genomic Analysis of Type VI Secretion Systems and Effectors in Klebsiella pneumoniae

Wanzhen Li et al.

Summary: This study provides new insights into the characteristics of T6SS in Klebsiella pneumoniae through in-depth comparative genomic analysis, revealing the prevalence and genetic features of T6SS in this bacterium. This contributes to future research on the mechanism and effectors of T6SS, potentially identifying proteins with novel antimicrobial properties.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Infectious Diseases

Virulence Genotype and Correlation of Clinical Severeness with Presence of the Type VI Secretion System in Klebsiella pneumoniae Isolates Causing Bloodstream Infections

Yin Zhang et al.

Summary: This study investigated the correlation and features of the type VI secretion system (T6SS) gene cluster in Klebsiella pneumoniae (K. pneumoniae), and found that T6SS-positive strains exhibited different pathogenicity and antibiotic resistance compared to T6SS-negative strains. T6SS-positive strains showed better performance in competition, antimicrobial resistance, and competition with Escherichia coli, but did not show significant differences in biofilm formation and survival rate in the presence of human serum compared to T6SS-negative strains.

INFECTION AND DRUG RESISTANCE (2022)

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Article Immunology

Metagenome Analysis of the Bacterial Characteristics in Invasive Klebsiella Pneumoniae Liver Abscesses

Zhijie Zhang et al.

Summary: This study found significant differences in bacterial characteristics between IKPLA and KPLA, including microbiological changes, activation of related metabolic pathways, and expression of pathogenic genes. These differences provide clues for exploring the mechanism of invasiveness in KPLA.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Development and validation of a prediction model based on clinical and CT features for invasiveness of K. pneumoniae liver abscess

Hairui Wang et al.

Summary: A risk prediction model for the invasiveness of KPLA was developed and validated, with age, blood glucose, imaging characteristics, and thrombophlebitis identified as independent risk factors for EMI.

EUROPEAN RADIOLOGY (2022)

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Article Medicine, Research & Experimental

Foeniculum vulgare seed extract induces apoptosis in lung cancer cells partly through the down-regulation of Bcl-2

Weiwei Ke et al.

Summary: Ethanol extract of Foeniculum vulgare seeds (EEFS) significantly reduces lung cancer cell growth by targeting Bcl-2 protein expression and inducing apoptosis in vitro and in vivo. This study provides evidence for the potential of EEFS as a therapeutic drug for lung cancer.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Immunology

The KbvR Regulator Contributes to Capsule Production, Outer Membrane Protein Biosynthesis, Antiphagocytosis, and Virulence in Klebsieila pneumoniae

Li Xu et al.

Summary: The transcription regulator KbvR in Klebsiella pneumoniae plays a crucial role in virulence and defense against the innate immune response by regulating the biosynthesis of capsular polysaccharide and some outer membrane proteins. Deletion of kbvR decreases the production of CPS and biosynthesis of OMPs, impacting bacterial pathogenicity. This discovery provides important insights into the pathogenesis of Klebsiella pneumoniae.

INFECTION AND IMMUNITY (2021)

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Article Immunology

Gut Microbiota Contributes to Host Defense Against Klebsiella pneumoniae-Induced Liver Abscess

Yahong Zheng et al.

Summary: The study identified the gut microbiota as a protective factor against K. pneumoniae infection, and found that FMT could improve inflammatory levels and liver damage in KLA patients, increasing survival rates.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Multidisciplinary Sciences

Sensing of intracellular Hcp levels controls T6SS expression in Vibrio cholerae

Kevin Manera et al.

Summary: The study reveals a quantity-sensing control mechanism of the T6SS, which down-regulates the expression of secreted components in the cytosol when T6SS is inactive. This Hcp-dependent sensing control allows organisms carrying T6SS to quickly adjust T6SS expression and prevent wasteful build-up of its major secreted components.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Gastroenterology & Hepatology

Virulence among different types of hypervirulent Klebsiella pneumoniae with multi-locus sequence type (MLST)-11, Serotype K1 or K2 strains

Tsui-Chin Wang et al.

Summary: This study compared two different types of hypervirulent K. pneumoniae and found significant differences in virulence levels when assessed in vitro and in vivo models, despite similar virulence gene profiles. ST11 strains showed lower serum and phagocytic resistance compared to serotype K1/K2 strains, and mouse lethality tests confirmed this difference.

GUT PATHOGENS (2021)

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Article Microbiology

Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells

Laura M. Nolan et al.

Summary: TraDIS is used to identify T6SS toxins in Pseudomonas aeruginosa, leading to the discovery of Tse8 which targets the transamidosome complex in target cells to inhibit protein synthesis. This study expands the range of cellular components targeted by T6SS and validates the global genomics approach for identifying T6SS toxins in T6SS-encoding bacteria.

NATURE MICROBIOLOGY (2021)

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Article Immunology

The hypermucoviscosity of hypervirulent K. pneumoniae confers the ability to evade neutrophil-mediated phagocytosis

Qi Xu et al.

Summary: The study revealed that Hypervirulent Klebsiella pneumoniae (HvKP) has weaker binding affinity to human cells compared to classic strains, and acquisition of rmpA or rmpA2-bearing plasmid leads to increased survival rate upon exposure to neutrophils. Overproduction of hypermucoviscosity, but not capsular polysaccharide, contributes to reduced binding and phagocytosis, enhancing HvKP virulence.

VIRULENCE (2021)

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Review Microbiology