4.6 Article

A Therapeutic Vaccine in Combination with Cyclic GMP-AMP Cures More Differentiated Melanomas in Mice

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

Khiem C. Lam et al.

Summary: This study reveals how the microbiota influences the immune components of the TME to improve cancer therapy. Modulating the microbiota can trigger the IFN-I-NK cell-DC axis within tumors, enhancing the efficacy of immune checkpoint blockade (ICB).
Article Multidisciplinary Sciences

Tumor immunological phenotype signature-based high-throughput screening for the discovery of combination immunotherapy compounds

Haiyan Wang et al.

Summary: Combination immunotherapy using AKIs has been found to reprogram TIP gene expression, promote T cell infiltration in TNBC, and enhance the efficacy of PD-1, suggesting a novel strategy for discovering combination immunotherapy compounds.

SCIENCE ADVANCES (2021)

Article Medicine, Research & Experimental

ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation

Mengjie Hu et al.

Summary: Inhibition of ATM can enhance immune checkpoint blockade therapy by promoting cytoplasmic leakage of mitochondrial DNA and activating the cGAS/STING pathway, delaying tumor growth, enhancing the efficacy of anti-PD-1 therapy, and increasing lymphocyte infiltration into the tumor microenvironment. Additionally, ATM mutations, especially nonsense mutations, can predict clinical benefits of ICB therapy.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Multidisciplinary Sciences

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

Seoyun Yum et al.

Summary: This study shows that STING can function independently of type I interferons and autophagy, and that TBK1 recruitment to STING is essential for antiviral and antitumor immunity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Oncology

STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer

Seung Joon Lee et al.

Summary: STING activation can normalize the peritoneal vascular and immune microenvironment, converting immunologically cold peritoneal tumors into T-cell-inflamed tumors and providing a rationale for a novel combination therapeutic strategy for peritoneal carcinomatosis in colon cancer.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Biochemistry & Molecular Biology

Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy

Eva Perez-Guijarro et al.

NATURE MEDICINE (2020)

Article Multidisciplinary Sciences

Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery

Yanpu He et al.

SCIENCE ADVANCES (2020)

Review Oncology

Combination of CTLA-4 and PD-1 blockers for treatment of cancer

Anand Rotte

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Biochemistry & Molecular Biology

Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma

Antoni Ribas et al.

NATURE MEDICINE (2019)

Review Immunology

Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

Aurelie Durgeau et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Engineering, Biomedical

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

Christopher B. Rodell et al.

NATURE BIOMEDICAL ENGINEERING (2018)

Article Immunology

HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways

Md Masud Alam et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

Melanoma treatment in review

Beatriz Domingues et al.

IMMUNOTARGETS AND THERAPY (2018)

Article Multidisciplinary Sciences

Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors

Yingjie Nie et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Genomic Classification of Cutaneous Melanoma

Rehan Akbani et al.

Article Biochemistry & Molecular Biology

BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells By Reactivating MEK and ERK Signaling

Berta Sanchez-Laorden et al.

SCIENCE SIGNALING (2014)

Article Cell Biology

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response

Pia Kvistborg et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Biotechnology & Applied Microbiology

Combined p19Arf and interferon-beta gene transfer enhances cell death of B16 melanoma in vitro and in vivo

C. A. Merkel et al.

CANCER GENE THERAPY (2013)

Article Medicine, General & Internal

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Multidisciplinary Sciences

Melanoma biology and new targeted therapy

Vanessa Gray-Schopfer et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines

VO Melnikova et al.

ONCOGENE (2004)

Article Biochemistry & Molecular Biology

Cancer immunotherapy: moving beyond current vaccines

SA Rosenberg et al.

NATURE MEDICINE (2004)