Effect of Patient and Family Centered I-PASS on adverse event rates in hospitalized children with complex chronic conditions

BackgroundChildren with complex chronic conditions (CCCs) are at risk for adverse events (AEs) during hospitalizations. ObjectiveWe compared the effect of Patient and Family Centered (PFC)I-PASS on AE rates in children with and without CCCs. Designs, Settings, and ParticipantsPatients were drawn from the PFCI-PASS study, which included 3106 hospitalized children from seven North American pediatric hospitals between December 2014 and January 2017. Main Outcome and MeasuresAn effect modification analysis did not show difference in the intervention on children with and without CCCs (RRR 0.81, 95% CI [0.59-1.10]; p = .2). ResultsIn multivariable analysis, the adjusted incidence rate ratiofor AEs in children with CCCs was 0.5 (95% CI = 0.3-0.9, p = .01) with PFC I-PASS exposure; there was no statistically significant change in AEs for children without CCCs [IRR 0.6 (95% CI = 0.3-1.2; p = .1)].

Automated summary

This study compared the impact of Patient and Family Centered (PFC) I-PASS on adverse event (AE) rates in children with and without complex chronic conditions (CCCs). The results showed that in the multivariable analysis, children with CCCs had a significantly lower adjusted incidence rate ratio for AEs with PFC I-PASS exposure (0.5, 95% CI=0.3-0.9, p = .01), while there was no significant change in AEs for children without CCCs (IRR 0.6, 95% CI=0.3-1.2, p = .1).