Bi-tailed N-cationic surfactant promoted green synthesis of 2-amino-5-oxo-4-alkyl-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile derivatives via multicomponent reaction

Diversely functionalized 2-amino-5-oxo-4-alkyl-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile derivatives were synthesized from substituted aromatic aldehydes, 4-hydroxy coumarin and malononitrile using benzethonium chloride as an easily available, less explored green catalyst and 1:4 (EtOH:H2O) as a green solvent via multicomponent reaction. All the products were thoroughly characterized by infrared (IR), H-1-NMR, C-13-NMR, and mass spectral analyses. Synthesized compounds were screened rule of five for drug-likeness and green matrix properties.

Automated summary

Diversely functionalized 2-amino-5-oxo-4-alkyl-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile derivatives were synthesized using benzethonium chloride as a green catalyst and 1:4 (EtOH:H2O) as a green solvent via multicomponent reaction. The synthesized compounds were characterized by various spectroscopic techniques and evaluated for drug likeness and green matrix properties.