☆ 4.4 Article

Synthesis of 5-spirocycle camptothecin using ring-closing metathesis strategy

JOURNAL OF HETEROCYCLIC CHEMISTRY (2023)

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Article Chemistry, Medicinal

Spirocyclic Scaffolds in Medicinal Chemistry

Kerstin Hiesinger et al.

Summary: Spirocyclic scaffolds are widely used in drugs, and the interest in nonplanar bioactive compounds is growing. This article summarizes different synthetic routes to obtain spirocyclic systems, discussing their impact on potency and selectivity, as well as changes in physicochemical properties and ADME in vitro and in vivo.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Pharmacology & Pharmacy