Transmission characteristics of infectious pathogen-laden aerosols in a negative-pressure operating room

The infectious pathogen-laden aerosols generated by infected patients have a significant impact on the safety of surgical staff in highly clean negative-pressure operating rooms. Understanding the transmission characteristics of infectious pathogen-laden aerosols is therefore essential. Therefore, in this study, we conducted experiments in a full-size negative-pressure operating room, and the Phi-X174 phage was used as a bioaerosol release source to investigate the migration and deposition of bioaerosols. The high-concentration spatial regions and highconcentration deposition surfaces of the bioaerosols in the operating room were determined. The results showed that there was a high concentration of bioaerosols in the vortex region below the medical lamp for extended periods of time. Three surgical staff members close to the patient's surgical site had high bioaerosol concentrations at their facial sampling points, with the highest concentration reaching 16,553 PFU/m3 . At the end of bioaerosol generation, 99.9% of the bioaerosols were discharged within 10 mins. The bioaerosol deposition rates per unit area were high at 1.48%/m2, 0.46%/m2 and 1.79%/m2 for the central control panel, storage cabinet, and door surface, respectively. This research can be used as a scientific reference for controlling bioaerosols and determining key disinfection parts in a negative-pressure operating room.

Automated summary

In this study, experiments were conducted in a full-size negative-pressure operating room using Phi-X174 phage as a bioaerosol release source to investigate the migration and deposition of bioaerosols. The results showed that the high concentration of bioaerosols in the operating room was mainly concentrated in the vortex region below the medical lamp, and the surgical staff had high bioaerosol concentrations at their facial sampling points. This research can be used as a scientific reference for controlling bioaerosols and determining key disinfection parts in a negative-pressure operating room.