Journal
ADVANCED MATERIALS
Volume 27, Issue 40, Pages 6125-6130Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502598
Keywords
chlorophyll; nanomaterials; photoacoustic imaging; supramolecular structures; tumor therapies
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Funding
- National Basic Research Program of China (973 Program) [2013CB932701]
- 100-Talent Program of the Chinese Academy of Sciences
- National Natural Science Foundation of China [21374026, 21304023, 51303036]
- Beijing Natural Science Foundation [2132053]
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An assembly-induced retention effect for enhanced tumor photoacoustic (PA) imaging and therapeutics is described. A responsive small-molecule precursor is prepared that simultaneously self-assembles into nanofibers in tumor sites that exhibit an assembly-induced retention effect, which results in an improved PA imaging signal and enhanced therapeutic efficacy. This successful proof-of-concept study paves the way to develop novel supramolecular biomaterials for cancer diagnostics and therapeutics.
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