Epidemiological trends and outcomes of primary biliary cholangitis in South Korea between 2009 and 2019

Article Gastroenterology & Hepatology

Environmental factors, medical and family history, and comorbidities associated with primary biliary cholangitis in Japan: a multicenter case-control study

Kosuke Matsumoto et al.

Summary: The study identified that poor environmental hygiene in childhood (vault toilets and unpaved roads) and chronic exposure to chemicals (smoking and hair dye use) are likely risk factors for the development of PBC in Japan.

JOURNAL OF GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

Ethnicity, disease severity, and survival in Canadian patients with primary biliary cholangitis

Surain B. Roberts et al.

Summary: In a diverse Canadian cohort of PBC patients, Indigenous Canadians have poorer liver transplant-free and event-free survival compared to White patients. They are more likely to have a clinical event before diagnosis and present with higher liver function test indicators, which persist during follow-up.

HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Widespread gaps in the quality of care for primary biliary cholangitis in UK

Mathuri Sivakumar et al.

Summary: This study reported on the first national audit in the UK assessing the quality of care and adherence to guidelines for PBC patients. The majority of hospitals did not meet all recommended EASL standards, with deficiencies particularly evident in optimal UDCA dosing, assessment of bone density, and clinical symptom evaluation. Further interventions are needed to improve guideline adherence and ultimately enhance patient outcomes.

FRONTLINE GASTROENTEROLOGY (2022)

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Review Gastroenterology & Hepatology

Incidence of Hepatocellular Carcinoma in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis

Yamini Natarajan et al.

Summary: The risk factors for hepatocellular carcinoma (HCC) in patients with primary biliary cholangitis (PBC) are not clear, but cirrhosis and male gender are shown to be significant factors in increasing HCC incidence. Further studies are needed to evaluate additional risk factors in this population and support current recommendations for HCC surveillance in PBC patients with cirrhosis.

DIGESTIVE DISEASES AND SCIENCES (2021)

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Article Gastroenterology & Hepatology

Changes in disease characteristics of primary biliary cholangitis: An observational retrospective study from 1982 to 2016

Masaaki Takamura et al.

Summary: Recent patients with primary biliary cholangitis have shown changes in disease characteristics, including an increase in male-to-female ratio, older age at diagnosis, higher response rates to ursodeoxycholic acid, and longer survival, particularly in those diagnosed early.

HEPATOLOGY RESEARCH (2021)

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Review Gastroenterology & Hepatology

Regional variation and temporal trend of primary biliary cholangitis epidemiology: A systematic review and meta-analysis

Tingting Lv et al.

Summary: The study estimated the incidence and prevalence of primary biliary cholangitis (PBC) worldwide, revealing significant regional differences with North America having the highest rates and Asia-Pacific the lowest. Additionally, there is an increasing trend in both PBC incidence and prevalence globally.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Current understanding of primary biliary cholangitis

Atsushi Tanaka

Summary: Primary biliary cholangitis (PBC) is an autoimmune disease that mainly affects middle-aged women but also young women and men. It is characterized by degeneration and necrosis of intrahepatic biliary epithelial cells, with early diagnosis through detection of antimitochondrial antibodies and introduction of ursodeoxycholic acid as first-line treatment significantly improving clinical outcomes.

CLINICAL AND MOLECULAR HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Male Sex Is Associated With Higher Rates of Liver-Related Mortality in Primary Biliary Cholangitis and Cirrhosis

Binu John et al.

Summary: In patients with PBC and well-compensated cirrhosis, male sex is associated with a higher risk of both death and liver-related death or transplantation.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Recent advances in clinical practice: epidemiology of autoimmune liver diseases

Palak J. Trivedi et al.

Summary: Autoimmune liver diseases, including primary biliary cholangitis, primary sclerosing cholangitis, and autoimmune hepatitis, show meaningful changes in disease epidemiology with increasing incidence and prevalence in Europe, North America, and the Asia-Pacific region. Global variations exist in contemporary incidence rates, with age, sex, and race impacting clinical outcomes and the need for gastroenterology, hepatology, and organ transplant services.

GUT (2021)

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Article Gastroenterology & Hepatology