☆ 4.7 Article

Qingyihuaji Formula promotes apoptosis and autophagy through inhibition of MAPK/ERK and PI3K/Akt/mTOR signaling pathway on pancreatic cancer in vivo and in vitro

JOURNAL OF ETHNOPHARMACOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Oncology

Autophagic Schwann cells promote perineural invasion mediated by the NGF/ATG7 paracrine pathway in pancreatic cancer

Wunai Zhang et al.

Summary: Autophagy and perineural invasion (PNI) in pancreatic cancer have negative effects on prognosis. Schwann cells (SCs) in PNI are activated through NGF-mediated autophagy, promoting PNI by enhancing migration and axon guidance towards cancer cells and increasing chemoattraction. Targeting NGF and autophagy for PNI treatment can block nerve infiltration.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Multidisciplinary Sciences

Prognostic significance of SHP2 (PTPN11) expression in solid tumors: A meta-analysis

Jiupeng Zhou et al.

Summary: This study conducted a meta-analysis to assess the prognostic value of SHP2 in tumor patients. The results showed that the expression of SHP2 was not significantly correlated with clinical stages, DFS, and OS in most solid tumors. However, the prognostic effect varied greatly with tumor sites, with SHP2 expression being positively related to early clinical stage in hepatocellular carcinoma and associated with shorter OS in pancreatic carcinoma and laryngeal carcinoma.

PLOS ONE (2022)

Add to Collection

Editorial Material Cell Biology

Crosstalk of Autophagy and Apoptosis

Maurizio Sorice

Summary: Autophagy and apoptosis are two fundamental mechanisms regulating cell fate, and they are significantly interconnected through various crosstalk mechanisms. The crosstalk between autophagy and apoptosis impacts various pathologies, including rheumatic diseases. This Special Issue focuses on investigating the bioactive properties of antitumor drugs, particularly the role of anthraquinone derivatives in regulating cell death and autophagy crosstalk.

CELLS (2022)

Add to Collection

Review Chemistry, Medicinal

Network Pharmacology Approach for Medicinal Plants: Review and Assessment

Fatima Noor et al.

Summary: The use of natural products, specifically medicinal plants, in medicine has proven to be crucial due to their ability to interact with cellular targets involved in diseases. Network pharmacology has emerged as a systematic paradigm in drug discovery, providing a comprehensive understanding of the bioactive components found in medicinal plants.

PHARMACEUTICALS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets

Damian Szklarczyk et al.

Summary: The STRING database integrates various associations between proteins, including physical interactions and functional associations, by collecting evidence from sources such as literature, databases, computational predictions, and systematic transfers. STRING aims for wide coverage and provides extensive user interface features and querying methods for experimental data.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Review Cell Biology

Quercetin Impact in Pancreatic Cancer: An Overview on Its Therapeutic Effects

Parina Asgharian et al.

Summary: Pancreatic cancer is a deadly malignancy with increasing mortality rates worldwide. The use of flavonoids like quercetin has shown promising anticancer abilities in controlling and treating pancreatic cancer.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Add to Collection

Review Oncology

Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance

Enrique Rozengurt et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, and recent literature on the complex crosstalk between KRAS, YAP, and Src tyrosine kinase family (SFK) in PDAC development and maintenance highlights new mechanistic and translational advances. Studies have shown the importance of RAS dimerization in signal transduction and how certain SFK members can phosphorylate and inhibit RAS function, suggesting a less crucial role for RAS in certain subtypes of PDAC. This points to the potential of targeting SFK to combat drug resistance and aggressive features in PDAC treatment.

CANCERS (2021)

Add to Collection

Review Medicine, General & Internal

Efficacy of Xiang-Sha-Liu-Jun-Zi on chemotherapy-induced nausea and vomiting A protocol for systematic review and meta-analysis

Hang Xiao et al.

Summary: This study aims to evaluate the effectiveness of Xiang-Sha-Liu-Jun-Zi (XSLJZ) in the treatment of chemotherapy-induced nausea and vomiting (CINV). By conducting a systematic review of randomized controlled trials, the latest evidence for treating CINV will be provided.

MEDICINE (2021)

Add to Collection

Review Pharmacology & Pharmacy

High-throughput proteomics and AI for cancer biomarker discovery

Qi Xiao et al.

Summary: This paper summarizes the advances and limitations of biomarkers in cancer research, as well as the important applications of mass spectrometry technology in proteomics. The article emphasizes the role of artificial intelligence technology in clinical studies, as well as the importance of combining computational and statistical methods in biomarker research.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Mechanism of interaction between autophagy and apoptosis in cancer

Shreya Das et al.

Summary: Autophagy and apoptosis play significant roles in cancer, but they may exhibit dual effects on cancer cell survival as the disease progresses. Interactions between a complex array of biomarkers are crucial in maintaining coordination between the two pathways, influencing the survival or death of malignant cells.

APOPTOSIS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Cancer cells dysregulate PI3K/AKT/mTOR pathway activation to ensure their survival and proliferation: mimicking them is a smart strategy of gammaherpesviruses

Mara Cirone

Summary: mTOR is the catalytic subunit of two complexes, mTORC1 and mTORC2, with distinct functions and can be activated by various signals; it integrates intracellular and extracellular signals to regulate cellular metabolism, growth, and survival; dysregulated activation of mTOR by the PI3K pathway is a common mechanism in cancer.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

Add to Collection

Review Environmental Sciences

A review on network pharmacology based phytotherapy in treating diabetes- An environmental perspective

Meenakshi R. Venkateswaran et al.

Summary: Diabetes is associated with obesity and cardiovascular diseases, with environmental factors and unhealthy dieting playing vital roles. Traditional herbal medicine can be an alternative therapy, but the lack of standardized procedures and knowledge on drug safety pose challenges. Heavy metal contamination from industrial and agricultural activities can make plants inappropriate for phytotherapy due to long-term health effects.

ENVIRONMENTAL RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology

STAT1 Is Required for Decreasing Accumulation of Granulocytic Cells via IL-17 during Initial Steps of Colitis-Associated Cancer

Yael Delgado-Ramirez et al.

Summary: The study demonstrates that the lack of STAT1 leads to increased tumorigenicity in colitis-associated colorectal cancer and this can be suppressed by neutralizing IL-17. The findings suggest that targeting IL-17 could potentially prevent tumor formation associated with STAT1 deficiency.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Medicine, General & Internal

Pancreatic Cancer: A Review

Wungki Park et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer with increasing incidence each year, resulting in a high percentage of patients being diagnosed with advanced disease. Current cytotoxic therapies for PDAC are moderately effective, emphasizing the importance of multidisciplinary management, comprehensive germline testing, and integrated supportive care for all patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Article Cell Biology

Caspase-3-mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway

Ziwen Zhang et al.

Summary: The study investigated the potential link between DOX-induced cell death and pyroptosis in two human breast cancer cell lines (MDA-MB-231 and T47D), confirming that DOX treatment reduced cell viability and induced pyroptosis morphology. Protein expression analyses highlighted GSDME as a key regulator in DOX-induced pyroptosis and emphasized the role of Caspase-3 activation. Furthermore, DOX treatments induced intracellular accumulation of ROS, JNK phosphorylation, and Caspase-3 activation.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Add to Collection

Review Oncology

Novel therapeutic strategies and perspectives for pancreatic cancer: Autophagy and apoptosis are key mechanisms to fight pancreatic cancer

Wenhao Luo et al.

Summary: Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract, and lack of effective treatments often leads to poor prognosis for patients. Resistance to apoptosis and autophagy is a key feature of PC, contributing to its invasiveness and resistance to conventional treatment. Natural product extracts show potential in inhibiting PC progression by affecting apoptosis or autophagy.

MEDICAL ONCOLOGY (2021)

Add to Collection

Review Gastroenterology & Hepatology

Cell death in pancreatic cancer: from pathogenesis to therapy

Xin Chen et al.

Summary: Pancreatic cancer is a devastating gastrointestinal cancer with late diagnosis, limited treatment success and poor prognosis, primarily composed of pancreatic ductal adenocarcinoma (PDAC). The occurrence and progression of PDAC are influenced by various factors, and the exact impact of cell death on PDAC is not yet well described.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Add to Collection

Article Chemistry, Medicinal

Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment

Kunpeng Wang et al.

Summary: This study investigated the pharmacological effects of Zuojin pills (ZJP) on pancreatic cancer using network pharmacology methods, revealing that ZJP may exert its anti-tumor effects through multiple compounds and signaling pathways, with a particular emphasis on the importance of the PI3K-AKT signaling pathway in treating pancreatic cancer.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Add to Collection

Article Pharmacology & Pharmacy

Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway

Lihua Cui et al.

Summary: Chaihu Guizhi Ganjiang Decoction (CGGD) showed effects in alleviating pancreatic damage, reducing collagen deposition, and inhibiting pancreatic stellate cell (PSC) activation in a rat model of chronic pancreatitis. By suppressing autophagy in PSCs through the JNK/mTOR signaling pathway, CGGD attenuated pancreatic fibrosis and PSC activation.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Article Oncology

Oridonin induces autophagy-mediated cell death in pancreatic cancer by activating the c-Jun N-terminal kinase pathway and inhibiting phosphoinositide 3-kinase signaling

Xin Zhao et al.

Summary: Oridonin inhibits the proliferation of pancreatic carcinoma cells and induces apoptosis, while mediating its effects on cell proliferation, apoptosis, and autophagy through simultaneous inhibition of the phosphoinositide 3-kinase pathway and activation of the c-Jun N-terminal kinase pathway.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Medicine, Research & Experimental

Selective autophagy of intracellular organelles: recent research advances

Wen Li et al.

Summary: Autophagy is a physiological process that degrades over-abundant or damaged organelles via the lysosomal system, induced by stress and occurring in both non-selective and selective manners. Selective autophagy plays a crucial role in maintaining cellular homeostasis and its dysfunction is implicated in various diseases.

THERANOSTICS (2021)

Add to Collection

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Add to Collection

Article Oncology

Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1

Kai Wang et al.

CANCER LETTERS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

Shannon Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Gastroenterology & Hepatology

Arenobufagin Inhibits the Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in Pancreatic Cancer Cells

Xiaolu Wei et al.

PANCREAS (2020)

Add to Collection

Article Immunology

Integrated Analyses Identify Immune-Related Signature Associated with Qingyihuaji Formula for Treatment of Pancreatic Ductal Adenocarcinoma Using Network Pharmacology and Weighted Gene Co-Expression Network

Xiang Qian et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Isoform-resolved correlation analysis between mRNA abundance regulation and protein level degradation

Barbora Salovska et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

Add to Collection

Article Medicine, Research & Experimental

Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways

Qiang Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Review Medicine, Research & Experimental

Anti -tumor activities and mechanisms of Traditional Chinese medicines formulas: A review

Yuqi Fan et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Article Oncology

Chinese Herbal Medicine Effectively Prolongs the Overall Survival of Pancreatic Cancer Patients: A Case Series

Wendy Wong et al.

INTEGRATIVE CANCER THERAPIES (2019)

Add to Collection

Article Biochemistry & Molecular Biology

MicroRNA-137 inhibits autophagy and chemosensitizes pancreatic cancer cells by targeting ATG5

Zhi-Chao Wang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

Add to Collection

Article Cell Biology

Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways

Shengnan Jia et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Review Oncology

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

Yuening Xiang et al.

CANCER MEDICINE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Qingyihuaji formula reverses gemcitabine resistant human pancreatic cancer through regulate lncRNA AB209630/miR-373/EphB2-NANOG signals

Peng Chen et al.

BIOSCIENCE REPORTS (2019)

Add to Collection

Article Integrative & Complementary Medicine

Utilising network pharmacology to explore the underlying mechanism of Wumei Pill in treating pancreatic neoplasms

Yuxiang Wan et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

Add to Collection

Article Multidisciplinary Sciences

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Yingyao Zhou et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Oncology

Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer

Tulasigeri M. Totiger et al.

MOLECULAR CANCER THERAPEUTICS (2019)

Add to Collection

Article Oncology

PAK1 Expression in Pancreatic Cancer: Clinicopathological Characteristics and Prognostic Significance

Nikolaos Symeonidis et al.

CLINICAL MEDICINE INSIGHTS-ONCOLOGY (2019)

Add to Collection

Article Oncology

Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells

Min Zhou et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

Ming-Chuan Hsu et al.

MOLECULAR CANCER (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein

Tsu-Yao Cheng et al.

ONCOGENE (2018)

Add to Collection

Review Pharmacology & Pharmacy

The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer

Ashfaq Ur Rehman et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

Add to Collection

Article Cell Biology

STAT1 facilitates oestrogen receptor α transcription and stimulates breast cancer cell proliferation

Yingxiang Hou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway

Libin Song et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2018)

Add to Collection

Article Oncology

Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway

Sunbin Ling et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2017)

Add to Collection

Article Integrative & Complementary Medicine

Babaodan Capsule combined with Qingyi Huaji Formula in advanced pancreatic cancer-a feasibility study

Li-bin Song et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2017)

Add to Collection

Article Multidisciplinary Sciences

A Label-Free Proteomic Analysis on Competent Larvae and Juveniles of the Pacific Oyster Crassostrea gigas

Pin Huan et al.

PLOS ONE (2015)

Add to Collection

Review Oncology

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

Xinbing Sui et al.

CANCER LETTERS (2014)

Add to Collection

Article Gastroenterology & Hepatology

Multimodality Treatment of Pancreatic Cancer With Liver Metastases Using Chemotherapy, Radiation Therapy, and/or Chinese Herbal Medicine

Huaqiang Ouyang et al.

PANCREAS (2011)

Add to Collection

Article Oncology

ONCOMINE: A cancer microarray database and integrated data-mining platform

DR Rhodes et al.

NEOPLASIA (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.