4.7 Article

Neoline, fuziline, songorine and 10-OH mesaconitine are potential quality markers of Fuzi: In vitro and in vivo explorations as well as pharmacokinetics, efficacy and toxicity evaluations

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1β-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-κB and MAPKs signaling pathways and inducing apoptosis

Chaocheng Guo et al.

Summary: The study found that FLA inhibited the activation of NF-kappa B and MAPKs signaling pathways in HFLS-RA, thereby inhibiting the expression and synthesis of inflammatory mediators, and induced apoptosis of HFLS-RA through the mitochondrial apoptosis pathway.

CYTOKINE (2022)

Review Medicine, Research & Experimental

An insight into current advances on pharmacology, pharmacokinetics, toxicity and detoxification of aconitine

Shiling Li et al.

Summary: Aconitine is a diterpenoid alkaloid with a wide range of pharmacological activities, including anti-tumor and anti-inflammatory effects. However, it also has toxic effects and may not be suitable for heart patients and pregnant women. Further research is needed to determine its clinical efficacy.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Integrative & Complementary Medicine

The Pseudotargeted Metabolomics Study on the Toxicity of Fuzi Using Ultraperformance Liquid Chromatography Tandem Mass Spectrometry

Huifei Wu et al.

Summary: This study identified the chemical components of Fuzi at different decoction times and investigated the detoxification mechanism of Glycyrrhizae Radix on Fuzi poisoning. The results showed that Glycyrrhizae Radix can effectively improve the toxic effects of Fuzi on rats and restore their metabolic profiles. This study demonstrates the importance of pseudotargeted metabolomics in studying the mechanisms of herbal toxicity.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

Article Pharmacology & Pharmacy

Exploring the mechanisms of neurotoxicity caused by fuzi using network pharmacology and molecular docking

Junsha An et al.

Summary: This study used network pharmacology and molecular docking technology to investigate the neurotoxicity mechanism of Fuzi, identified multiple targets and pathways, and confirmed the mechanism of neurotoxicity caused by aconitine.

FRONTIERS IN PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

Two New Alkaloids from Fuzi and Their Metabolites Study

Sisi Liu et al.

Summary: Four alkaloids were isolated from Fuzi in this study, two of which were newly discovered and the other two were reported NMR data for the first time. Their chemical structures were identified through various analyses, and the MS fragmentation patterns were explored, revealing the metabolic pathways of hetisane alkaloid.

CHEMISTRY & BIODIVERSITY (2021)

Review Biochemistry & Molecular Biology

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Amin Mahmood Thawabteh et al.

Summary: Diterpenoid alkaloids are complex natural compounds primarily produced by plants and marine organisms, with potential medicinal and toxic effects, exhibiting a wide range of biological activities. This review focuses on the structure, classification, toxicity, and bioactivity of natural diterpenoid alkaloids.

MOLECULES (2021)

Review Integrative & Complementary Medicine

The toxicology and detoxification of Aconitum: traditional and modern views

Yau-Tuen Chan et al.

Summary: This review examines the traditional and modern practices of using Aconitum-derived herbal medicine, discussing its toxicity and clinical management. It emphasizes the importance of safety awareness and the application of modern scientific knowledge when using Aconitum herbs.

CHINESE MEDICINE (2021)

Review Pharmacology & Pharmacy

Neuropharmacological effects of Aconiti Lateralis Radix Praeparata

Lihong Zhao et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2020)

Article Biochemical Research Methods

Synergistic effect of Aconiti Lateralis Radix Praeparata water-soluble alkaloids and Ginseng Radix et Rhizoma total ginsenosides compatibility on acute heart failure rats

Meichen Liu et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2020)

Article Chemistry, Analytical

Pharmacokinetics and tissue distribution of eighteen major alkaloids of Aconitum carmichaelii in rats by UHPLC-QQQ-MS

Yida Zhang et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2020)

Review Biochemistry & Molecular Biology

Overview of Neurological Mechanism of Pain Profile Used for Animal Pain-Like Behavioral Study with Proposed Analgesic Pathways

Mun Fei Yam et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Plant Sciences

Potentially Cardiotoxic Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii

Xingxing Zong et al.

JOURNAL OF NATURAL PRODUCTS (2019)

Review Chemistry, Medicinal

Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum

Haroon Khan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Organic

New C19-diterpenoid alkaloids from the parent roots of Aconitum carmichaelii

Xing-Xing Zong et al.

TETRAHEDRON LETTERS (2017)

Review Pharmacology & Pharmacy

A review on phytochemistry, pharmacology and toxicology studies of Aconitum

Eric Nyirimigabo et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2015)

Review Integrative & Complementary Medicine

Pharmacological effects of Chinese herb aconite (Fuzi) on cardiovascular system

Dandan Zhao et al.

JOURNAL OF TRADITIONAL CHINESE MEDICINE (2012)

Review Toxicology

Aconite poisoning

Thomas Y. K. Chan

CLINICAL TOXICOLOGY (2009)

Review Plant Sciences

Aconitum in Traditional Chinese Medicine-A valuable drug or an unpredictable risk?

Judith Singhuber et al.

JOURNAL OF ETHNOPHARMACOLOGY (2009)