Anti-inflammatory and antinociceptive activities of Daniellia oliveri (Fabaceace) stem bark extract

Article Plant Sciences

Ananas comosus (L) Merrill (pineapple) fruit peel extract demonstrates antimalarial, anti-nociceptive and anti-inflammatory activities in experimental models

Abayomi M. Ajayi et al.

Summary: Pineapple peel extract demonstrated mild antimalarial activity but significant antinociceptive and anti-inflammatory properties, possibly through inhibition of pro-inflammatory mediators.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Chemical Fingerprinting, Antioxidant, and Anti-Inflammatory Potential of Hydroethanolic Extract of Trigonella foenum-graecum

Hina Fatima et al.

Summary: This study evaluated the antioxidant and anti-inflammatory potential of hydroethanolic extract of T. foenum-graecum seeds. The extract exhibited significant antioxidant activity and was non-toxic to human and murine cells. It also showed a concentration-dependent reduction in inflammatory markers and improved antioxidant levels against oxidative stress. The hydroethanolic extract of T. foenum-graecum is a potential source of phenolic compounds with antioxidant and anti-inflammatory properties.

ANTIOXIDANTS (2022)

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Article Multidisciplinary Sciences

Antinociceptive effects of a hydroethanolic stem bark extract of Burkea africana

Yakubu Jibira et al.

Summary: Pain is a major symptom of many clinical disorders, and finding new effective drugs for pain management is a global need. The stem bark of the African savanna tree Burkea africana is used in traditional medicine in Ghana to treat various pain-related diseases. Research has found that the extract from the stem bark has antinociceptive effects, possibly through the involvement of 5-HT3 receptors and opioidergic pathways.

HELIYON (2022)

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Article Medicine, Research & Experimental

PA-Int5: An isatin-thiosemicarbazone derivative that exhibits anti-nociceptive and anti-inflammatory effects in Swiss mice

Aldilane Goncalves Da Fonseca et al.

Summary: This study aimed to investigate the CNS performance, anti-nociceptive, and anti-inflammatory activity of the compound PA-Int5. The results demonstrated that PA-Int5 exhibited anti-nociceptive and anti-inflammatory activities without affecting motor coordination in treated mice.

BIOMEDICAL REPORTS (2021)

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Article Plant Sciences

Involvement of opioidergic and GABAergic systems in the anti-nociceptive activity of the methanolic extract of Cuscuta Epithymum Murr. in mice

Behrooz Khakpour Taleghani et al.

Summary: This study found that the extract of CE has potential anti-nociceptive effects, which may be mediated by opioidergic and GABAergic systems.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Chemical constituents and anti-inflammatory activity of the total alkaloid extract from Melodinus cochinchinensis (Lour.) Merr. and its inhibition of the NF-κB and MAPK signaling pathways

Meilian Yang et al.

Summary: The study identified 21 monoterpenoid indole alkaloids (MIAs) in MCTA, with aspidospermine- and quinolone-type alkaloids as major compounds. MCTA demonstrated significant anti-inflammatory effects by inhibiting the activation of NF-kappa B and MAPK pathways in both in vitro and in vivo assessments.

PHYTOMEDICINE (2021)

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Article Medicine, Research & Experimental

Chrysophyllum albidum fruit ethanol extract ameliorates hyperglycaemia and elevated blood pressure in streptozotocin-induced diabetic rats through modulation of oxidative stress, NF-κB and PPAR-γ

Abayomi M. Ajayi et al.

Summary: This study confirmed that Chrysophyllum albidum fruit extract can lower STZ-induced hyperglycemia, improve blood pressure and lipid profiles in diabetic rats, reduce oxidative stress, and increase antioxidant markers levels.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Parasitology

Filaricidal activity of Daniellia oliveri and Psorospermum febrifugum extracts

Melanie Abongwa et al.

Summary: In this study, extracts from Daniellia oliveri and Psorospermum febrifugum were found to be effective against parasitic roundworms such as Onchocerca ochengi and Brugia pahangi, supporting their traditional use in the treatment of onchocerciasis and LF. Further purification of these extracts could lead to the discovery and development of lead compounds for filarial drug.

PARASITES & VECTORS (2021)

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Article Immunology