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Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2023)

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Targeted Pulmonary Delivery of the Green Tea Polyphenol Epigallocatechin Gallate Controls the Growth of Mycobacterium tuberculosis by Enhancing the Autophagy and Suppressing Bacterial Burden

Ankur Sharma et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Dynamic mucus penetrating microspheres for efficient pulmonary delivery and enhanced efficacy of host defence peptide (HDP) in experimental tuberculosis

Ankur Sharma et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Preparation and characterization of sustained release pirfenidone loaded microparticles for pulmonary drug delivery: Spray drying approach

Sagar Pardeshi et al.

DRYING TECHNOLOGY (2020)

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Inhaled nanoparticles-An updated review

Tuangrat Praphawatvet et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery

Andrew M. Shen et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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CFD Guided Optimization of Nose-to-Lung Aerosol Delivery in Adults: Effects of Inhalation Waveforms and Synchronized Aerosol Delivery

Rabijit Dutta et al.

PHARMACEUTICAL RESEARCH (2020)

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Chemo-photodynamic therapy by pulmonary delivery of gefitinib nanoparticles and 5-aminolevulinic acid for treatment of primary lung cancer of rats

Tongtong Zhang et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2020)

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Nebulized ivermectin for COVID-19 and other respiratory diseases, a proof of concept, dose-ranging study in rats

Carlos Chaccour et al.

SCIENTIFIC REPORTS (2020)

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Modifying and Integrating in vitro and ex vivo Respiratory Models for Inhalation Drug Screening

Aylin Cidem et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Pharmacology & Pharmacy

Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers

Maria F. Acosta et al.

AAPS JOURNAL (2020)

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Article Nanoscience & Nanotechnology

Matrix Metalloproteinase-Responsive Mesoporous Silica Nanoparticles Cloaked with Cleavable Protein for Self-Actuating On-Demand Controlled Drug Delivery for Cancer Therapy

Kalpesh Vaghasiya et al.

ACS APPLIED BIO MATERIALS (2020)

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Fluorescent Mantle Carbon Coated Core-Shell SPIONs for Neuroengineering Applications

Ashish Tiwari et al.

ACS APPLIED BIO MATERIALS (2020)

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Advanced spray dried proliposomes of amphotericin B lung surfactant-mimic phospholipid microparticles/nanoparticles as dry powder inhalers for targeted pulmonary drug delivery

Alexan I. Gomez et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2020)

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Article Medicine, General & Internal

Nanotoxicity: a challenge for future medicine

Ramazan Akcan et al.

TURKISH JOURNAL OF MEDICAL SCIENCES (2020)

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Review Medicine, Research & Experimental

Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications

Karel Smetana et al.

IN VIVO (2020)

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DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment

Zerong Li et al.

DRUG DELIVERY (2020)

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Article Pharmacology & Pharmacy

Mycobactericidal activity of some micro-encapsulated synthetic Host Defense Peptides (HDP) by expediting the permeation of antibiotic: A new paradigm of drug delivery for tuberculosis

Ankur Sharma et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Recent advances in aerosolised drug delivery

Akshay Chandel et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Tadalafil nanocomposites as a dry powder formulation for inhalation, a new strategy for pulmonary arterial hypertension treatment

Rayehe Teymouri Rad et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Review Biotechnology & Applied Microbiology

Recent advances in gelatin-based therapeutics

Mari Carmen Echave et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2019)

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Scale-up of pharmaceutical spray drying using scale-up rules: A review

Sadegh Poozesh et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Experimental investigation of aerosol deposition through a realistic respiratory airway replica: An evaluation for MDI and DPI performance

Kaveh Ahookhosh et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Materials Science, Biomaterials

A multilayer hollow nanocarrier for pulmonary co-drug delivery of methotrexate and doxorubicin in the form of dry powder inhalation formulation

Saeideh Nozohouri et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Biological Obstacles for Identifying In Vitro-In Vivo Correlations of Orally Inhaled Formulations

Eleonore Froehlich

PHARMACEUTICS (2019)

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Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus

Aleksandra Loczechin et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Challenges and strategies in drug delivery systems for treatment of pulmonary infections

Duy-Khiet Ho et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Review Chemistry, Multidisciplinary

Rational particle design to overcome pulmonary barriers for obstructive lung diseases therapy

Yuan He et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Modeling Airflow and Particle Deposition in a Human Acinar Region

Arun V. Kolanjiyil et al.

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2019)

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Ethambutol-Loaded Solid Lipid Nanoparticles as Dry Powder Inhalable Formulation for Tuberculosis Therapy

Elham Nemati et al.

AAPS PHARMSCITECH (2019)

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Review Biotechnology & Applied Microbiology

Nanomedicine Approaches for the Pulmonary Treatment of Cystic Fibrosis

Cecilia Velino et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Multiscale in silico lung modeling strategies for aerosol inhalation therapy and drug delivery

Pantelis Koullapis et al.

CURRENT OPINION IN BIOMEDICAL ENGINEERING (2019)

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Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world

Minakshi Prasad et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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An efficient computational fluid-particle dynamics method to predict deposition in a simplified approximation of the deep lung

P. G. Koullapis et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

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Article Pharmacology & Pharmacy

Regional aerosol deposition in the human airways: The SimInhale benchmark case and a critical assessment of in silico methods

P. Koullapis et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

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Article Pharmacology & Pharmacy

Reclaiming hijacked phagosomes: Hybrid nano-in-micro encapsulated MIAP peptide ensures host directed therapy by specifically augmenting phagosome-maturation and apoptosis in TB infected macrophage cells

Ankur Sharma et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Challenges for pulmonary delivery of high powder doses

Imco Sibum et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Powder Particles and Technologies for Medicine Delivery to the Respiratory System: Challenges and Opportunities

Tomasz R. Sosnowski

KONA POWDER AND PARTICLE JOURNAL (2018)

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Article Biotechnology & Applied Microbiology

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

Ema Robinson et al.

MOLECULAR THERAPY (2018)

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Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung

Aristides D. Tagalakis et al.

THORAX (2018)

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Article Chemistry, Multidisciplinary

Age-Dependent Rat Lung Deposition Patterns of Inhaled 20 Manometer Gold Nanoparticles and their Quantitative Biokinetics in Adult Rats

Wolfgang G. Kreyling et al.

ACS NANO (2018)

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Polyester-based particles to overcome the obstacles of mucus and biofilms in the lung for tobramycin application under static and dynamic fluidic conditions

Julia Ernst et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

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Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)

Prashant Das et al.

PLOS ONE (2018)

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Mesh nebulizers have become the first choice for new nebulized pharmaceutical drug developments

John N. Pritchard et al.

THERAPEUTIC DELIVERY (2018)

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Review Pharmacology & Pharmacy

Nano-Based Anti-Tubercular Drug Delivery and Therapeutic Interventions in Tuberculosis

Rohit Sharma et al.

CURRENT DRUG TARGETS (2017)

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High drug-loading nanomedicines: progress, current status, and prospects

Shihong Shen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Innovative pMDI formulations of spray-dried nanoparticles for efficient pulmonary drug delivery

Hao-Ying Li et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Respiratory System

Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity

Zsofia Edit Papay et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2017)

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Comparison of traditional intranasal and aerosol inhalation inoculation of guinea pigs with visualizing influenza virus

Yi Zhang et al.

JOURNAL OF AEROSOL SCIENCE (2017)

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Three-dimensional unsteady large eddy simulation of the vortex structures and the mono-disperse particle dispersion in the idealized human upper respiratory system

Xinguang Cui et al.

JOURNAL OF AEROSOL SCIENCE (2017)

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Article Engineering, Chemical

Pulmonary aerosol transport and deposition analysis in upper 17 generations of the human respiratory tract

Mohammad S. Islam et al.

JOURNAL OF AEROSOL SCIENCE (2017)

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Article Medicine, Research & Experimental

Nanoparticles of pH-Responsive, PEG-Doxorubicin Conjugates: Interaction with an in Vitro Model of Lung Adenocarcinoma and Their Direct Formulation in Propellant-Based Portable Inhalers

K. S. V. Krishna Rao et al.

MOLECULAR PHARMACEUTICS (2017)

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Article Chemistry, Multidisciplinary

Anti-Tuberculosis Bacteriophage D29 Delivery with a Vibrating Mesh Nebulizer, Jet Nebulizer, and Soft Mist Inhaler

Nicholas B. Carrigy et al.

PHARMACEUTICAL RESEARCH (2017)

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Review Cardiac & Cardiovascular Systems

Optimizing drug delivery in COPD: The role of inhaler devices

Paola Rogliani et al.

RESPIRATORY MEDICINE (2017)

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Review Genetics & Heredity

Advances in Non-Viral DNA Vectors for Gene Therapy

Cinnamon L. Hardee et al.

GENES (2017)

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Allergic respiratory disease (ARD), setting forth the basics: proposals of an expert consensus report

Ana M. Navarro et al.

CLINICAL AND TRANSLATIONAL ALLERGY (2017)

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Animal models of asthma: utility and limitations

Marcelo Vivolo Aun et al.

JOURNAL OF ASTHMA AND ALLERGY (2017)

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Review Immunology

Heterogeneity in tuberculosis

Anthony M. Cadena et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Building dry powder formulations using supercritical CO2 spray drying

Ana Aguiar-Ricardo

CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY (2017)

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Review Chemistry, Multidisciplinary

Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers: challenges and opportunities

Sharad Mangal et al.

ACTA PHARMACOLOGICA SINICA (2017)

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Article Biotechnology & Applied Microbiology

Inhalable chitosan nanoparticles as antitubercular drug carriers for an effective treatment of tuberculosis

Tarun Garg et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2016)

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Review Pharmacology & Pharmacy

Amorphous powders for inhalation drug delivery

Lan Chen et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery

Gemma O'Connor et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Article Pharmacology & Pharmacy

Itraconazole-loaded nanostructured lipid carriers (NLC) for pulmonary treatment of aspergillosis in falcons

Jana Pardeike et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2016)

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Review Nanoscience & Nanotechnology

Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges

Shadabul Haque et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

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Microdialysis as a way to measure antibiotics concentration in tissues

Sandrine Marchand et al.

PHARMACOLOGICAL RESEARCH (2016)

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Article Toxicology

Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity

A. Hess et al.

TOXICOLOGY IN VITRO (2016)

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Design of boronic acid-attributed carbon dots on inhibits HIV-1 entry

M. Z. Fahmi et al.

RSC ADVANCES (2016)

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Microparticulate/nanoparticulate powders of a novel Nrf2 activator and an aerosol performance enhancer for pulmonary delivery targeting the lung Nrf2/Keap-1 pathway

Priya Muralidharan et al.

MOLECULAR SYSTEMS DESIGN & ENGINEERING (2016)

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In Vitro Testing for Orally Inhaled Products: Developments in Science-Based Regulatory Approaches

Ben Forbes et al.

AAPS JOURNAL (2015)

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Pharmacokinetics of Orally Inhaled Drug Products

Guenther Hochhaus et al.

AAPS JOURNAL (2015)

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Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

Alejandro Sosnik et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2015)

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Three-dimensional inspiratory flow in the upper and central human airways

A. J. Banko et al.

EXPERIMENTS IN FLUIDS (2015)

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Cystic Fibrosis Gene Therapy in the UK and Elsewhere

Uta Griesenbach et al.

HUMAN GENE THERAPY (2015)

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Article Cardiac & Cardiovascular Systems

Delivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Pulmonary Arterial Hypertension

Satoshi Akagi et al.

International Heart Journal (2015)

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Pulmonary drug delivery: a review on nanocarriers for antibacterial chemotherapy

M. Moreno-Sastre et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2015)

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Nanotechnology approaches for inhalation treatment of lung diseases

Andriy Kuzmov et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Quantitative detection of drug dose and spatial distribution in the lung revealed by Cryoslicing Imaging

Nirav Barapatre et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2015)

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Review Biochemistry & Molecular Biology

Nanostructures for the Inhibition of Viral Infections

Sabine Szunerits et al.

MOLECULES (2015)

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Inhalable nanoparticulate powders for respiratory delivery

Priya Muralidharan et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

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Non-Animal Models of Epithelial Barriers (Skin, Intestine and Lung) in Research, Industrial Applications and Regulatory Toxicology

Sarah Gordon et al.

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2015)

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Evaluation of nano spray drying as a method for drying and formulation of therapeutic peptides and proteins

Yusuf A. Haggag et al.

FRONTIERS IN PHARMACOLOGY (2015)

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Nanotoxicity: An Interplay of Oxidative Stress, Inflammation and Cell Death

Puja Khanna et al.

NANOMATERIALS (2015)

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Development and Analysis of Patient-Based Complete Conducting Airways Models

Rafel Bordas et al.

PLOS ONE (2015)

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Nanotechnology-based inhalation treatments for lung cancer: state of the art

Javed Ahmad et al.

NANOTECHNOLOGY SCIENCE AND APPLICATIONS (2015)

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Review Pharmacology & Pharmacy

Emerging aerosol drug delivery strategies: From bench to clinic

Bruce K. Rubin et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

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Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor

Mahboobe Ghaedi et al.

BIOMATERIALS (2014)

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Spray freeze drying for dry powder inhalation of nanoparticles

Mohamed Ehab Ali et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

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Article Pharmacology & Pharmacy

Montelukast-loaded nanostructured lipid carriers: Part I Oral bioavailability improvement

Arpana Patil-Gadhe et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

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Review Biochemistry & Molecular Biology

Nanoparticle-Mediated Pulmonary Drug Delivery: A Review

Mukta Paranjpe et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

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MR imaging and targeting of a specific alveolar macrophage subpopulation in LPS-induced COPD animal model using antibody-conjugated magnetic nanoparticles

Achraf Al Faraj et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2014)

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Article Chemistry, Multidisciplinary

DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma

Adriana L. da Silva et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Across the pulmonary epithelial barrier: Integration of physicochemical properties and human cell models to study pulmonary drug formulations

Mehra Haghi et al.

PHARMACOLOGY & THERAPEUTICS (2014)

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Formulation considerations for dry powder inhalers

Eike Cordts et al.

THERAPEUTIC DELIVERY (2014)

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Jet, Ultrasonic, and Mesh Nebulizers: An Evaluation of Nebulizers for Better Clinical Outcomes

Arzu Ari

EURASIAN JOURNAL OF PULMONOLOGY (2014)

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Article Pharmacology & Pharmacy

The Smart Targeting of Nanoparticles

Adam Friedman et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

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In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals

Kamrun Nahar et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

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Article Chemistry, Medicinal

New co-spray-dried tobramycin nanoparticles-clarithromycin inhaled powder systems for lung infection therapy in cystic fibrosis patients

Gabrielle Pilcer et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

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Article Toxicology

Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

Marianne Geiser et al.

PARTICLE AND FIBRE TOXICOLOGY (2013)

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Functional Testing of an Inhalable Nanoparticle Based Influenza Vaccine Using a Human Precision Cut Lung Slice Technique

Vanessa Neuhaus et al.

PLOS ONE (2013)

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Mechanisms of absorption and elimination of drugs administered by inhalation

Mariam Ibrahim et al.

THERAPEUTIC DELIVERY (2013)

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Breathing Resistance and Ultrafine Particle Deposition in Nasal-Laryngeal Airways of a Newborn, an Infant, a Child, and an Adult

Jinxiang Xi et al.

ANNALS OF BIOMEDICAL ENGINEERING (2012)

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Article Chemistry, Medicinal

Development of an inhalation chamber and a dry powder inhaler device for administration of pulmonary medication in animal model

Biswadip Sinha et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2012)

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Article Nanoscience & Nanotechnology

Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in solid lipid nanoparticles

Wenrui Wang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2012)

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Article Chemistry, Multidisciplinary

Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery

Moritz Beck-Broichsitter et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Review Chemistry, Multidisciplinary

Doxil® - The first FDA-approved nano-drug: Lessons learned

Yechezkel (Chezy) Barenholz

JOURNAL OF CONTROLLED RELEASE (2012)

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Article Medicine, Research & Experimental

Partial Biodistribution and Pharmacokinetics of Isoniazid and Rifabutin Following Pulmonary Delivery of Inhalable Microparticles to Rhesus Macaques

Rahul Kumar Verma et al.

MOLECULAR PHARMACEUTICS (2012)

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Article Toxicology

Comparative Computational Modeling of Airflows and Vapor Dosimetry in the Respiratory Tracts of Rat, Monkey, and Human

Richard A. Corley et al.

TOXICOLOGICAL SCIENCES (2012)

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Review Respiratory System

Pulmonary drug delivery strategies: A concise, systematic review

J. S. Patil et al.

LUNG INDIA (2012)

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Editorial Material Pharmacology & Pharmacy

Nano-based theranostics for chronic obstructive lung diseases: challenges and therapeutic potential

Neeraj Vij

EXPERT OPINION ON DRUG DELIVERY (2011)

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Influence of particle size on regional lung deposition - What evidence is there?

Thiago C. Carvalho et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

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Article Biophysics

Computational Fluid Dynamics Simulations of Particle Deposition in Large-Scale, Multigenerational Lung Models

D. Keith Walters et al.

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2011)

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Article Chemistry, Multidisciplinary

Inhalable nanoparticles, a non-invasive approach to treat lung cancer in a mouse model

Wilson H. Roa et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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TOXICOLOGY OF NANOMATERIALS USED IN NANOMEDICINE

Jinshun Zhao et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2011)

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Aerosol drug delivery: developments in device design and clinical use

Myrna B. Dolovich et al.

LANCET (2011)

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Inhaled therapies for tuberculosis and the relevance of activation of lung macrophages by particulate drug-delivery systems

Rahul Kumar Verma et al.

THERAPEUTIC DELIVERY (2011)

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Review Pharmacology & Pharmacy

Pulmonary delivery of inhalable nanoparticles: dry powder inhalers

M. H. D. Kamal Al-Hallak et al.

THERAPEUTIC DELIVERY (2011)

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Article Pharmacology & Pharmacy

A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung

M. Nassimi et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2010)

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Review Pharmacology & Pharmacy

Formulation strategy and use of excipients in pulmonary drug delivery

Gabrielle Pilcer et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

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Article Engineering, Biomedical

CFD Simulation of Aerosol Deposition in an Anatomically Based Human Large-Medium Airway Model

Baoshun Ma et al.

ANNALS OF BIOMEDICAL ENGINEERING (2009)

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Article Cell Biology

Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model

Yukiko Matsuo et al.

CELLULAR IMMUNOLOGY (2009)

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Article Pharmacology & Pharmacy

Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model

Moritz Beck-Broichsitter et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2009)

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Article Multidisciplinary Sciences

Alveolar duct expansion greatly enhances aerosol deposition: a three-dimensional computational fluid dynamics study

C. Darquenne et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2009)

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Article Respiratory System

Generation of lung epithelial-like tissue from human embryonic stem cells

Lindsey Van Haute et al.

RESPIRATORY RESEARCH (2009)

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Modeling human lung disease in animals

Lorraine B. Ware

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

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Article Engineering, Biomedical

Targeted Drug-Aerosol Delivery in the Human Respiratory System

C. Kleinstreuer et al.

Annual Review of Biomedical Engineering (2008)

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Article Microbiology

Intracellular time course, pharmacokinetics, and biodistribution of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to mice

Rahul Kumar Verma et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)

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Article Chemistry, Medicinal

Current therapies and technological advances in aqueous aerosol drug delivery

Alan B. Watts et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2008)

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Article Pharmacology & Pharmacy

A hand-held apparatus for nose-only exposure of mice to inhalable microparticles as a dry powder inhalation targeting lung and airway macrophages

Jatinder Kaur et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2008)

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Review Biochemistry & Molecular Biology

In vitro cell culture models for the assessment of pulmonary drug disposition

Jennifer L. Sporty et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)

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Review Nanoscience & Nanotechnology

Drug delivery and nanoparticles: Applications and hazards

Wim H. De Jong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2008)

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Review Pharmacology & Pharmacy

Inhaled nanoparticles - A current review

Wei Yang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Article Respiratory System

Short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols;: The detailed pharmacokinetics of budesonide, formoterol, and terbutaline

Per Ewing et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2008)

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Article Respiratory System

In vitro/in vivo comparisons in pulmonary drug delivery

Stephen P. Newman et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2008)

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Article Pharmacology & Pharmacy

Advanced Nebulizer Designs Employing Vibrating Mesh/Aperture Plate Technologies for Aerosol Generation

J. Waldrep et al.

Current Drug Delivery (2008)

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Review Pharmacology & Pharmacy

In vivo animal models for drug delivery across the lung mucosal

Sally-Ann Cryan et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

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Article Engineering, Chemical

Numerical simulation of aerosol deposition in a 3-D human nasal cavity using RANS, RANS/EIM, and LES

Yuan Liu et al.

JOURNAL OF AEROSOL SCIENCE (2007)

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Article Medicine, General & Internal

Nanotherapeutics: new challenges for safety and cost-effectiveness regulation in Australia

Thomas A. Faunce

MEDICAL JOURNAL OF AUSTRALIA (2007)

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Review Pharmacology & Pharmacy

In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery

Masahiro Sakagami

ADVANCED DRUG DELIVERY REVIEWS (2006)

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Review Pharmacology & Pharmacy

Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery

Sunday A. Shoyele et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)

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Article Biotechnology & Applied Microbiology

Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution

MW Konstan et al.

HUMAN GENE THERAPY (2004)

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Article Pharmacology & Pharmacy

Pulmonary delivery of therapeutic peptides via dry powder inhalation: effects of micronisation and manufacturing

M Irngartinger et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2004)

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Article Toxicology

A novel method to aerosolize powder for short inhalation exposures at high concentrations: Isolated rat lungs exposed to respirable diesel soot

P Gerde et al.

INHALATION TOXICOLOGY (2004)

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Article Critical Care Medicine

Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers

MT Newhouse et al.

CHEST (2003)

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Article Chemistry, Medicinal

Evaluation of nose-only aerosol inhalation chamber and comparison of experimental results with mathematical simulation of aerosol deposition in mouse lungs

V Nadithe et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2003)

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Article Pharmacology & Pharmacy

Drug absorption from the isolated perfused rat lung-correlations with drug physicochemical properties and epithelial permeability

A Tronde et al.

JOURNAL OF DRUG TARGETING (2003)

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Review Public, Environmental & Occupational Health

Cascade impactors for the size characterization of aerosols from medical inhalers: Their uses and limitations

JP Mitchell et al.

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG (2003)

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Article Public, Environmental & Occupational Health

Miniaturized nebulization catheters:: A new approach for delivery of defined aerosol doses to the rat lung

A Tronde et al.

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG (2002)

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Article Pharmacology & Pharmacy

Global Initiative for Chronic Obstructive Lung Diseases (GOLD)

SS Hurd et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2002)

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Article Pharmacology & Pharmacy

Drug targeting

VP Torchilin

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2000)

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