Targeting a Hallmark of Crohn's Disease: Browning of the Hypertrophic Mesenteric Adipose Tissue as a Novel Strategy to Reduce Inflammation?

Article Gastroenterology & Hepatology

Characteristics of mesenteric adipose tissue attached to different intestinal segments and their roles in immune regulation

Haowei Zhang et al.

Summary: This study reveals the differences between mesenteric adipose tissue (MAT) adjacent to the small and large intestines in terms of morphology, gene expression, cell components, and immune and microbiota regulation. These findings will guide future research to investigate the specialized roles of different MATs in intestinal health and disease.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2022)

Add to Collection

Article Gastroenterology & Hepatology

Role of the Mesentery in Crohn's Terminal Ileitis

Marte A. J. Becker et al.

Summary: The presence of mesenteric alterations in Crohn's disease has long been acknowledged, but their functional and clinical consequences remain debatable. Guidelines recommend limited resection without removal of adjacent mesentery to prevent complications, but recent studies propose mesenteric resection as an alternative to reduce disease recurrence in Crohn's patients.

CLINICS IN COLON AND RECTAL SURGERY (2022)

Add to Collection

Review Endocrinology & Metabolism

Beige Adipose Tissue Identification and Marker Specificity-Overview

Anna-Claire Pilkington et al.

Summary: Adipose tissue is classified based on its characteristics, but differentiating beige adipose tissue (BeAT) remains a challenge. Recent research focuses on identifying different types of adipose tissue through transcript markers to advance understanding of their biology. The development of concrete strategies to distinguish types of adipose tissue may be crucial for improving metabolic health and preventing excessive weight gain.

FRONTIERS IN ENDOCRINOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Role of Adipose Tissue in Inflammatory Bowel Disease

Eva Karaskova et al.

Summary: Inflammatory bowel diseases (IBDs), such as Crohn's disease and ulcerative colitis, are chronic inflammatory disorders affecting the gastrointestinal tract. Obesity, particularly visceral adiposity, plays a significant role in the pathogenesis of IBD, influencing disease severity and clinical outcomes. Visceral adipose tissue is actively involved in lipid storage, immunological and endocrine activity, serving as a barrier to inflammation and potentially the main source of cytokines and adipokines associated with IBD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology