4.8 Review

Wielding the double-edged sword: Redox drug delivery systems for inflammatory bowel disease

Related references

Note: Only part of the references are listed.
Article Nanoscience & Nanotechnology

Biomimetic MOF Nanoparticles Delivery of C-Dot Nanozyme and CRISPR/Cas9 System for Site-Specific Treatment of Ulcerative Colitis

Yana Ma et al.

Summary: This study developed a biomimetic pH-responsive carrier for the precise treatment of ulcerative colitis (UC). The biomimetic nanoparticles exhibited pH-responsive, immune escape, and inflammation targeting capabilities, effectively reducing inflammation symptoms and the expression of pro-inflammatory cytokines both in vitro and in vivo.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Engineering, Biomedical

Endothelial cell-targeting, ROS-ultrasensitive drug/siRNA co-delivery nanocomplexes mitigate early-stage neutrophil recruitment for the anti-inflammatory treatment of myocardial ischemia reperfusion injury

Mengying Hou et al.

Summary: Neutrophils play a critical role in myocardial ischemia reperfusion injury (MIRI) due to their unregulated activation and infiltration. Researchers developed endothelial cell-targeting nanocomplexes that efficiently co-delivered VCAM-1 siRNA and dexamethasone, effectively inhibiting neutrophil recruitment and reducing inflammation.

ACTA BIOMATERIALIA (2022)

Article Chemistry, Multidisciplinary

Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases

Mengying Hou et al.

Summary: In this study, cell-membrane-based nanodecoys were developed to treat autoimmune diseases by interrupting the self-promoted inflammatory cascade. These nanodecoys showed high accumulation levels and scavenging efficiency, inhibiting T cell activation and restoring immune tolerance, thus alleviating autoimmune damages.

ADVANCED MATERIALS (2022)

Article Pharmacology & Pharmacy

SHARP hydrogel for the treatment of inflammatory bowel disease

Lenka Polakova et al.

Summary: Inflammatory bowel disease (IBD) is a global inflammatory disease affecting millions of people. A new hydrogel system utilizing an antioxidant polymer has shown promising results in treating acute colitis in mice models, offering a potential strategy for IBD treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Article Biochemistry & Molecular Biology

ROS-Sensitive Polymer Micelles for Selective Degradation in Primary Human Monocytes from Patients with Active IBD

Elena Gardey et al.

Summary: Inflammatory bowel disease (IBD) is characterized by increased levels of reactive oxygen species (ROS) in inflamed areas of the gastrointestinal tract and in circulating immune cells. Oxidation-responsive polymeric nanostructures selectively degrade in the presence of H2O2, providing opportunities for targeted drug delivery in IBD patients.

MACROMOLECULAR BIOSCIENCE (2022)

Article Materials Science, Biomaterials

Reactive oxygen species-scavenging hollow MnO2 nanozymes as carriers to deliver budesonide for synergistic inflammatory bowel disease therapy

Huiqiang Qiu et al.

Summary: This study presents a novel drug delivery system utilizing nanoparticles loaded with budesonide in dextran sulfate sodium-coated hollow mesoporous manganese dioxide nanoparticles to target activated macrophages, scavenge ROS, and release anti-inflammatory drugs. The synergistic effect of the ROS-scavenging hMnO(2) carriers and anti-inflammatory drug provides a more effective treatment for IBD, reducing side effects and improving treatment outcomes compared to free Bud. This research offers a promising approach for the design of highly effective synergistic anti-inflammatory nanomedicines.

BIOMATERIALS SCIENCE (2022)

Article Chemistry, Physical

Microfluidic encapsulated manganese organic frameworks as enzyme mimetics for inflammatory bowel disease treatment

Guopu Chen et al.

Summary: Metal organic frameworks (MOFs) are proposed as attractive materials for their adjustable structures and physicochemical properties, with a focus on developing functional materials with catalytic capabilities for biomedical values. Biocompatible manganese metal organic framework (Mn-MOF)-based catalase mimetics with microfluidic microcapsule encapsulation were presented for intravital inflammatory bowel disease (IBD) treatment. These Mn-MOF-encapsulated microcapsules showed high performance in treating spontaneous IBD in interleukin-10-deficient mice by relieving oxidative stress and reducing inflammation.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

Article Chemistry, Multidisciplinary

Nanoreactor for cascade reaction between SOD and CAT and its tissue regeneration effect

Kiyoon Kwon et al.

Summary: In this study, a nanoreactor was designed to reduce overproduced reactive oxygen species (ROS) in inflammatory diseases and facilitate the regeneration of damaged inflamed tissues. The nanoreactor, loaded with dual antioxidant enzymes, enhanced the cascade reaction and showed a synergistic anti-inflammatory effect. The efficacy of the nanoreactor for tissue regeneration was confirmed in a mouse model.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Pharmacology & Pharmacy

A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis

Zhejie Chen et al.

Summary: With the assistance of polyphenols, a handy delivery strategy has been proposed for efficient in vivo delivery of IL-10 mRNA, showing potential for the treatment of ulcerative colitis.

ACTA PHARMACEUTICA SINICA B (2022)

Review Biochemistry & Molecular Biology

The Antioxidant Effect of the Metal and Metal-Oxide Nanoparticles

Xuemei Ge et al.

Summary: This paper illustrates the excellent performance of inorganic nanoparticles in antioxidant effect, including smaller and controllable sizes, flexibility to be modified, relative low toxicity and ease of preparation. The antioxidant mechanism of these nanoparticles, such as antioxidant enzyme-mimetic activity and antioxidant ROS/RNS scavenging activity, is introduced. The paper summarizes the antioxidant effects and applications of several nanoparticles and investigates the potential toxicity for further applications. Furthermore, the future directions of utilizing these inorganic nanoparticles in fields such as medicine, cosmetic and functional food additives are explored.

ANTIOXIDANTS (2022)

Article Nanoscience & Nanotechnology

Yeast Microcapsule Mediated Natural Products Delivery for Treating Ulcerative Colitis through Anti-Inflammatory and Regulation of Macrophage Polarization

Xingxing Feng et al.

Summary: This study designed a macrophages-targeting oral drug delivery system for ulcerative colitis, using berberine and Epigallocatechin Gallate encapsulated in yeast microcapsules. The system effectively transported the drugs to inflammation sites and exerted anti-inflammatory effects through the interaction with macrophage receptors. It provided a new targeting strategy for UC treatment.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Physical

Orally administered covalently-assembled antioxidative peptide nanoparticles for inflammatory bowel disease therapy

Xiaoyan Ma et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammation disease that requires improved therapeutic options. The covalent assembly of casein phosphopeptide (CPP) into nanoparticles (GCPP NPs) provides a solution to enhance stability and antioxidation efficacy for the treatment of IBD. The GCPP NPs demonstrated robustness, stability, and efficient accumulation at inflamed sites, leading to potential oral administration for anti-inflammatory treatment of IBD.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

Review Food Science & Technology

Polyphenols intervention is an effective strategy to ameliorate inflammatory bowel disease: a systematic review and meta-analysis

Liu Fang et al.

Summary: The systematic review and meta-analysis on polyphenols as an adjuvant therapy for IBD revealed that curcumin treatment significantly improved clinical remission in both intention-to-treat and per-protocol analyses. Further clinical trials are needed to confirm the effects of polyphenols on IBD due to the limited number of studies included in the present review.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2021)

Article Medicine, Research & Experimental

Oral Delivery of β-Lactoglobulin-Nanosphere-Encapsulated Resveratrol Alleviates Inflammation in Winnie Mice with Spontaneous Ulcerative Colitis

Naisarg Pujara et al.

Summary: Resveratrol complexation with BLG enhances its solubility and stability, leading to improved anti-inflammatory activity in a mouse model of IBD. This study highlights the potential of biocompatible nanomaterials for oral delivery of poorly soluble anti-inflammatory agents.

MOLECULAR PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Improving silymarin oral bioavailability using silica-installed redox nanoparticle to suppress inflammatory bowel disease

Thu-Ha Thi Nguyen et al.

Summary: The study developed silica-containing redox nanoparticles to improve the bioavailability of silymarin, demonstrating the potential for treating inflammatory bowel diseases (IBD).

JOURNAL OF CONTROLLED RELEASE (2021)

Article Gastroenterology & Hepatology

The four epidemiological stages in the global evolution of inflammatory bowel disease

Gilaad G. Kaplan et al.

Summary: The global burden of inflammatory bowel disease is evolving into four epidemiological stages: Emergence, Acceleration in Incidence, Compounding Prevalence, and Prevalence Equilibrium. Developing countries, newly industrialized countries, and Western regions are in different stages of disease evolution.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Nanoscience & Nanotechnology

Antioxidant Enzymes Sequestered within Lipid-Polymer Hybrid Nanoparticles for the Local Treatment of Inflammatory Bowel Disease

Zhicheng Le et al.

Summary: This study developed safe and efficient local drug delivery systems for treating inflammatory bowel disease by encapsulating SOD in lipid-polymer hybrid nanoparticles, which exhibited good enzymatic stability and activity. The nanoparticles with PEG coating and folate functionalization showed excellent mucu-penetrating ability and inflammation-targeting properties, enhancing mucosal retention time and drug delivery efficiency within the colorectal region. The findings suggest that antioxidant enzymes sequestered within lipid-polymer hybrid nanoparticles could be potential enzyme therapeutics for local treatment of inflammatory diseases in the future.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Food Science & Technology

Development and evaluation of a novel nanofibersolosome for enhancing the stability, in vitro bioaccessibility, and colonic delivery of cyanidin-3-O-glucoside

Mohammad Rezaul Islam Shishir et al.

Summary: The study developed novel nanofibersolosomes for colonic delivery of cyanidin-3-O-glucoside, showing higher stability and bioactivity during gastrointestinal digestion and colonic fermentation compared to traditional lipid formulations. The nanofibersolosomes efficiently delivered higher concentrations of C3G to the colon and exhibited potential for delivering other hydrophilic labile phytochemicals, warranting further evaluation in vivo models.

FOOD RESEARCH INTERNATIONAL (2021)

Article Engineering, Biomedical

Mesopore to Macropore Transformation of Metal-Organic Framework for Drug Delivery in Inflammatory Bowel Disease

Yi Yin et al.

Summary: Ce-MOF@PSS preferentially adheres to inflamed intestine and releases drug locally to effectively treat inflammatory bowel disease.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Medicine, Research & Experimental

Smart Responsive Quercetin-Conjugated Glycol Chitosan Prodrug Micelles for Treatment of Inflammatory Bowel Diseases

Cuiyun Shen et al.

Summary: The GC-B-Que micelles exhibit pH/ROS dual-responsive properties and sustained release behavior, showing better therapeutic efficacy than free drugs in treating colitis. These micelles have the potential for oral delivery and provide an alternative strategy for designing smart responsive nanocarriers for catechol-based drugs.

MOLECULAR PHARMACEUTICS (2021)

Review Chemistry, Physical

Redox-active nanoparticles for inflammatory bowel disease

Qinjuan Ren et al.

Summary: Maintaining gut microbiota homeostasis is crucial for nutrient metabolism and immune function. Inflammatory bowel disease (IBD) is strongly linked to dysregulation of gut microbiota, with reactive oxygen and nitrogen species playing a detrimental role in causing inflammation and dysbiosis. Redox-active nanoparticles show potential in regulating IBD by scavenging ROS and RNS, but their long-term effects on normal microbiota from widespread use in commercial products need attention.

NANO RESEARCH (2021)

Article Engineering, Biomedical

Construction of pH-Dependent Nanozymes with Oxygen Vacancies as the High-Efficient Reactive Oxygen Species Scavenger for Oral-Administrated Anti-Inflammatory Therapy

Ning Zhao et al.

Summary: The study introduces a novel nanozyme NiCo2O4@PVP with good biocompatibility and reactive oxygen species (ROS) scavenging ability for treating inflammatory bowel disease (IBD). NiCo2O4@PVP can pass through the digestive tract and target the inflamed site for oral-administrated anti-inflammatory therapy, resulting in a significant decrease in the expression levels of inflammatory factors in the colon.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

Oral delivery of antioxidant enzymes for effective treatment of inflammatory disease

Zhiying Zeng et al.

Summary: The approach of encapsulating native antiinflammatory proteins in wind chimes like cyclodextrin (WCC) for oral protein delivery is effective in enhancing stability and delivery efficiency. The integration of SOD and CAT in WCC nanovehicles shows synergistic effects in inhibiting inflammatory response, as demonstrated in a mouse colitis model.

BIOMATERIALS (2021)

Article Gastroenterology & Hepatology

609 ELUCIDATING THE COMPLEX ROLE OF DIETARY FIBERS IN MEDIATING INFLAMMATION AND BARRIER INTEGRITY IN IBD

Heather Armstrong et al.

GASTROENTEROLOGY (2021)

Article Nanoscience & Nanotechnology

Genistein-Derived ROS-Responsive Nanoparticles Relieve Colitis by Regulating Mucosal Homeostasis

Wentao Fan et al.

Summary: GEN-NP2 effectively delivers GEN to inflammatory sites, protects it from rapid metabolism and elimination in the gastrointestinal tract, and alleviates colitis. This nanoparticle increases the expression of estrogen receptor beta (ERβ), reduces the expression of proinflammatory mediators, modulates the gut microbiota, and ultimately relieves colitis.

ACS APPLIED MATERIALS & INTERFACES (2021)

Review Pharmacology & Pharmacy

Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems

Zhejie Chen et al.

Summary: Polyphenols, as naturally occurring bioactive products, have shown great potential in medical intervention of various diseases due to their special molecular structure. They play a multifaceted role in novel drug delivery systems, acting both as therapeutic agents and essential components of drug carriers. However, the active biochemical characteristics of polyphenols pose challenges for their high-frequency use in drug delivery systems.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

Drug delivery to the inflamed intestinal mucosa - targeting technologies and human cell culture models for better therapies of IBD

Olga Hartwig et al.

Summary: Current treatment strategies for IBD aim to alleviate the undesirable symptoms of the disorder, with both conventional and newer therapeutic options benefiting from various targeting strategies. The development and evaluation of targeted delivery systems require suitable in vivo and in vitro models, with a focus on human in vitro models of IBD discussed in this review. Advancements in biology- and nanotechnology-based targeted drug delivery systems are elaborated on, along with potential areas for improvement to facilitate clinical translation.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Biochemistry & Molecular Biology

Broad-Spectrum Reactive Oxygen Species Scavenging and Activated Macrophage-Targeting Microparticles Ameliorate Inflammatory Bowel Disease

Jiawei Li et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease with excessively high levels of reactive oxygen species (ROS) in the colon. Fabricating broad-spectrum ROS scavenging and activated macrophage-targeting microparticles (MPs) can effectively treat IBD by reducing inflammation and targeting activated macrophages.

BIOMACROMOLECULES (2021)

Article Pharmacology & Pharmacy

Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis

Patricia Diez-Echave et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with limited effectiveness in current pharmacological treatments. Research suggests that loading quercetin in silk fibroin nanoparticles may have anti-inflammatory effects and serve as a promising treatment for IBD.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

ROS-responsive microcapsule assembly from Turkish galls for ulcerative colitis therapy

Yonghao Liu et al.

Summary: This study presents a galltannin-metal microcapsule system for the treatment of ulcerative colitis, which has been shown to possess anti-inflammatory and therapeutic effects both in vitro and in vivo. The system demonstrates antioxidant properties and sensitivity to hydrogen peroxide, providing a potential candidate drug carrier for UC therapeutics.

NEW JOURNAL OF CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

One-step prepared nano-in-micro microcapsule delivery vehicle with sequential burst-sustained drug release for the targeted treatment of inflammatory bowel disease

Jingjing Jiang et al.

Summary: Orally targeted drug delivery using a pH-responsive nano-in-micro composite is effective for treating inflammatory bowel disease (IBD). This drug delivery system allows for sequential burst-sustained drug release under colonic pH, achieving high drug concentration and quick reduction of inflammation. The success of this model demonstrates its potential for IBD therapy.

MATERIALS CHEMISTRY FRONTIERS (2021)

Article Materials Science, Biomaterials

Oral nanotherapeutics with enhanced mucus penetration and ROS-responsive drug release capacities for delivery of curcumin to colitis tissues

Yamei Huang et al.

Summary: Functionalized PLGA-based nanoparticles with pluronic F127 and co-encapsulated catalase (CAT) and curcumin (CUR) showed enhanced mucus penetration, improved cellular uptake by macrophages, and increased release rate of CUR in an H2O2-rich environment. They also exhibited stronger inhibition of pro-inflammatory cytokines secretion and better therapeutic outcomes for ulcerative colitis (UC) compared to other nanoparticles. These results suggest that these mucus-penetrating nanoparticles loaded with CAT and CUR can be utilized as effective nanotherapeutics for UC therapy.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Pharmacology & Pharmacy

One-Pot Synthesis of pH-Responsive Eudragit-Mesoporous Silica Nanocomposites Enable Colonic Delivery of Glucocorticoids for the Treatment of Inflammatory Bowel Disease

Zhi Qu et al.

Summary: The study proposes a smart drug delivery system using functionalized mesoporous silica nanoparticles and pH-responsive polymer to improve the release efficiency and reduce systemic side effects of oral glucocorticoids. Results show that this system can release drugs at colonic pH and demonstrate therapeutic efficacy in a mouse colitis model. Coated nanoparticles significantly decrease cytokine expression in the proximal colon, indicating colonic delivery effectiveness.

ADVANCED THERAPEUTICS (2021)

Article Gastroenterology & Hepatology

Long-term outcome of immunomodulator use in pediatric patients with inflammatory bowel disease

Karen van Hoeve et al.

DIGESTIVE AND LIVER DISEASE (2020)

Article Biochemistry & Molecular Biology

Human erythrocytes exposure to juglone leads to an increase of superoxide anion production associated with cytochrome b5 reductase uncoupling

Gabriel N. Valerio et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2020)

Review Biotechnology & Applied Microbiology

The challenge and prospect of mRNA therapeutics landscape

Yuhua Weng et al.

BIOTECHNOLOGY ADVANCES (2020)

Article Chemistry, Multidisciplinary

Strain Effect in Palladium Nanostructures as Nanozymes

Zheng Xi et al.

NANO LETTERS (2020)

Review Gastroenterology & Hepatology

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

Aonghus Lavelle et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Pharmacology & Pharmacy

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Sang Hoon Lee et al.

PHARMACEUTICS (2020)

Article Gastroenterology & Hepatology

Su1181 THE ROLE OF INFLAMMATION IN REDOX HOMEOSTASIS IN IBD PATIENTS

Michal Kloska et al.

GASTROENTEROLOGY (2020)

Review Medicine, Research & Experimental

Bilirubin Nanomedicines for the Treatment of Reactive Oxygen Species (ROS)-Mediated Diseases

Zhejie Chen et al.

MOLECULAR PHARMACEUTICS (2020)

Review Gastroenterology & Hepatology

JAK-STAT pathway targeting for the treatment of inflammatory bowel disease

Azucena Salas et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Chemistry, Multidisciplinary

Polyphenol-Mediated Assembly for Particle Engineering

Jiajing Zhou et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

Article Pharmacology & Pharmacy

Ascorbyl-dipalmitate-stabilised nanoemulsions as a potential localised treatment of inflammatory bowel diseases

M. Plaza-Oliver et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Pharmacology & Pharmacy

Oral delivery of oleuropein-loaded lipid nanocarriers alleviates inflammation and oxidative stress in acute colitis

Amaia Huguet-Casquero et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Multidisciplinary Sciences

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Yufeng Liu et al.

SCIENCE ADVANCES (2020)

Review Plant Sciences

Astragali Radix (Huangqi): A promising edible immunomodulatory herbal medicine

Zhejie Chen et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

Article Chemistry, Multidisciplinary

An Orally Administered CeO2@Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy

Shengwc. Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Review Food Science & Technology

Dietary polyphenols for managing cancers: What have we ignored?

Xu Wu et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

Article Cell Biology

Gastrointestinal synthetic epithelial linings

Junwei Li et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Biotechnology & Applied Microbiology

The double-edged sword effect of macrophage targeting delivery system in different macrophage subsets related diseases

Yuchuan Yuan et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Article Medicine, Research & Experimental

Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine

Tianlei Sun et al.

THERANOSTICS (2020)

Review Pharmacology & Pharmacy

Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives

Niranjan G. Kotla et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Review Chemistry, Multidisciplinary

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Yanyan Huang et al.

CHEMICAL REVIEWS (2019)

Article Biophysics

Superoxide dismutase in nanoarchaeosomes for targeted delivery to inflammatory macrophages

Priscila Schilrreff et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

Article Pharmacology & Pharmacy

Oral administration of colitis tissue-accumulating porous nanoparticles for ulcerative colitis therapy

Qiubing Chen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

Review Chemistry, Multidisciplinary

Reactive Oxygen Species (ROS)-Based Nanomedicine

Bowen Yang et al.

CHEMICAL REVIEWS (2019)

Review Biochemistry & Molecular Biology

Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection

Kathryn Burge et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Materials Science, Biomaterials

Modular Assembly of Biomaterials Using Polyphenols as Building Blocks

Junling Guo et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

Review Biochemistry & Molecular Biology

Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System

Huan Ye et al.

BIOMACROMOLECULES (2019)

Article Chemistry, Multidisciplinary

Therapeutic mRNA delivery to leukocytes

Yasmin Granot-Matok et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Review Chemistry, Physical

Supramolecular design and applications of polyphenol-based architecture: A review

Hongshan Liang et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2019)

Article Biochemistry & Molecular Biology

Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release

Nieves Iglesias et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biotechnology & Applied Microbiology

Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities

Fatemeh Farjadian et al.

NANOMEDICINE (2019)

Article Chemistry, Multidisciplinary

A self-assembled, ROS-responsive Janus-prodrug for targeted therapy of inflammatory bowel disease

Shanshan Li et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Review Gastroenterology & Hepatology

Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease

Uday N. Shivaji et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2019)

Review Chemistry, Multidisciplinary

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Jiangjiexing Wu et al.

CHEMICAL SOCIETY REVIEWS (2019)

Review Chemistry, Multidisciplinary

Nanozyme: new horizons for responsive biomedical applications

Dawei Jiang et al.

CHEMICAL SOCIETY REVIEWS (2019)

Article Medicine, Research & Experimental

Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease

Jiulong Zhao et al.

THERANOSTICS (2019)

Review Gastroenterology & Hepatology

Environmental triggers in IBD: a review of progress and evidence

Ashwin N. Ananthakrishnan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Article Nanoscience & Nanotechnology

Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice

Jiulong Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Article Immunology

Oral engineered Bifidobacterium longum expressing rhMnSOD to suppress experimental colitis

Mengge Liu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

Article Polymer Science

Oxidation-responsive micelles by a one-pot polymerization-induced self-assembly approach

Fabian H. Sobotta et al.

POLYMER CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation

Jia Yao et al.

CHEMICAL SCIENCE (2018)

Article Chemistry, Medicinal

Cell-Based Kinetic Target-Guided Synthesis of an Enzyme Inhibitor

Henrik Antti et al.

ACS MEDICINAL CHEMISTRY LETTERS (2018)

Review Chemistry, Physical

Biomedical applications of mRNA nanomedicine

Qingqing Xiong et al.

NANO RESEARCH (2018)

Article Biotechnology & Applied Microbiology

Promising therapeutic effect of gold nanoparticles against dinitrobenzene sulfonic acid-induced colitis in rats

Rehab M. Hussein et al.

NANOMEDICINE (2018)

Article Chemistry, Multidisciplinary

Green Fabrication of Ovalbumin Nanoparticles as Natural Polyphenol Carriers for Ulcerative Colitis Therapy

Shuangquan Gou et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2018)

Review Pharmacology & Pharmacy

Reactive oxygen species: key regulators in vascular health and diseases

Qishan Chen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

G. Aviello et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Gastroenterology & Hepatology

Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases

Mingming Sun et al.

JOURNAL OF GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

The Gut Microbiota in Inflammatory Bowel Disease

Donal Sheehan et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2017)

Article Gastroenterology & Hepatology

Microbiomarkers in inflammatory bowel diseases: caveats come with caviar

Felix Sommer et al.

Review Chemistry, Multidisciplinary

Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

Hirotaka Ejima et al.

NANO TODAY (2017)

Review Nanoscience & Nanotechnology

Safety of nanosuspensions in drug delivery

Lulu Wang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

Review Gastroenterology & Hepatology

Gut microbiota and IBD: causation or correlation?

Josephine Ni et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Review Microbiology

The resilience of the intestinal microbiota influences health and disease

Felix Sommer et al.

NATURE REVIEWS MICROBIOLOGY (2017)

Review Biotechnology & Applied Microbiology

Bilirubin enzyme biosensor: potentiality and recent advances towards clinical bioanalysis

Vinita Hooda et al.

BIOTECHNOLOGY LETTERS (2017)

Article Biochemistry & Molecular Biology

Schiff base complexes of copper and zinc as potential anti-colitic compounds

Elaine M. Conner et al.

BIOMETALS (2017)

Article Food Science & Technology

Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl/6 mice

Elisa Giner et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2016)

Article Chemistry, Multidisciplinary

Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy

Yonghyun Lee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Review Biochemistry & Molecular Biology

Mitochondrial ROS regulation of proliferating cells

Lauren Diebold et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Pharmacology & Pharmacy

Zein-alginate based oral drug delivery systems: Protection and release of therapeutic proteins

Sungmun Lee et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Article Chemistry, Multidisciplinary

Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers

Wei Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species (ROS) Responsive Polymers for Biomedical Applications

Qinghua Xu et al.

MACROMOLECULAR BIOSCIENCE (2016)

Editorial Material Biotechnology & Applied Microbiology

Do ginger-derived nanoparticles represent an attractive treatment strategy for inflammatory bowel diseases?

Mingzhen Zhang et al.

NANOMEDICINE (2016)

Article Medicine, Research & Experimental

Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study

Maryam Samsami-kor et al.

ARCHIVES OF MEDICAL RESEARCH (2015)

Article Chemistry, Multidisciplinary

Ultra-sensitive ROS-responsive tellurium-containing polymers

Wei Cao et al.

CHEMICAL COMMUNICATIONS (2015)

Article Chemistry, Multidisciplinary

A study of the uptake and biodistribution of nano-titanium dioxide using in vitro and in vivo models of oral intake

Alan MacNicoll et al.

JOURNAL OF NANOPARTICLE RESEARCH (2015)

Review Gastroenterology & Hepatology

Nanomedicines in gastroenterology and hepatology

Alf Lamprecht

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)

Article Gastroenterology & Hepatology

The global burden of IBD: from 2015 to 2025

Gilaad G. Kaplan

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)

Review Gastroenterology & Hepatology

Epidemiology and risk factors for IBD

Ashwin N. Ananthakrishnan

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)

Article Polymer Science

Reactive oxygen species (ROS)-responsive tellurium-containing hyperbranched polymer

Ruochen Fang et al.

POLYMER CHEMISTRY (2015)

Review Immunology

The resolution of inflammation: Principles and challenges

Sarah E. Headland et al.

SEMINARS IN IMMUNOLOGY (2015)

Article Materials Science, Biomaterials

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

Jamie E. Rayahin et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

Article Materials Science, Biomaterials

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

Jamie E. Rayahin et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

Article Multidisciplinary Sciences

Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection

Dan Elgrabli et al.

PLOS ONE (2015)

Review Immunology

Innate and adaptive immunity in inflammatory bowel disease

Alessandra Geremia et al.

AUTOIMMUNITY REVIEWS (2014)

Review Immunology

Leukocyte Migration into Inflamed Tissues

Sussan Nourshargh et al.

IMMUNITY (2014)

Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

Article Gastroenterology & Hepatology

Efficacy of zinc-carnosine chelate compound, Polaprezinc, enemas in patients with ulcerative colitis

Munenori Itagaki et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2014)

Article Gastroenterology & Hepatology

Immunopathology of inflammatory bowel disease

Kori L. Wallace et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Article Materials Science, Biomaterials

Oxidation-responsive polymers for biomedical applications

Cheng-Cheng Song et al.

JOURNAL OF MATERIALS CHEMISTRY B (2014)

Review Oncology

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Simran S. Sabharwal et al.

NATURE REVIEWS CANCER (2014)

Review Chemistry, Multidisciplinary

Selenium-Containing Polymers: Promising Biomaterials for Controlled Release and Enzyme Mimics

Huaping Xu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2013)

Review Biochemistry & Molecular Biology

The dynamics of gut-associated microbial communities during inflammation

Sebastian E. Winter et al.

EMBO REPORTS (2013)

Article Environmental Sciences

Bio-distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice

Suzanne Marie Hirst et al.

ENVIRONMENTAL TOXICOLOGY (2013)

Review Pharmacology & Pharmacy

Approaches for enhancing oral bioavailability of peptides and proteins

Jwala Renukuntla et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Article Chemistry, Multidisciplinary

Enzyme Sensitive Synthetic Polymer Micelles Based on the Azobenzene Motif

Jingyi Rao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Multidisciplinary Sciences

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Yukihiro Furusawa et al.

NATURE (2013)

Article Multidisciplinary Sciences

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

Takashi Satoh et al.

NATURE (2013)

Article Multidisciplinary Sciences

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

Amandine Everard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Engineering, Biomedical

Current Progress in Reactive Oxygen Species (ROS)-Responsive Materials for Biomedical Applications

Sue Hyun Lee et al.

ADVANCED HEALTHCARE MATERIALS (2013)

Review Immunology

Beyond oxidative stress: an immunologist's guide to reactive oxygen species

Carl Nathan et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Review Medicine, Research & Experimental

Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence

Hong Zhu et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2012)

Review Pharmacology & Pharmacy

Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease

Bo Xiao et al.

EXPERT OPINION ON DRUG DELIVERY (2012)

Article Gastroenterology & Hepatology

An Orally Administered Redox Nanoparticle That Accumulates in the Colonic Mucosa and Reduces Colitis in Mice

Long Binh Vong et al.

GASTROENTEROLOGY (2012)

Article Agriculture, Multidisciplinary

Metabolism of Anthocyanins by Human Gut Microflora and Their Influence on Gut Bacterial Growth

Maria Hidalgo et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)

Article Chemistry, Multidisciplinary

Biocompatible Polymeric Nanoparticles Degrade and Release Cargo in Response to Biologically Relevant Levels of Hydrogen Peroxide

Caroline de Gracia Lux et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Review Gastroenterology & Hepatology

The gut microbiota in IBD

Chaysavanh Manichanh et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

Review Gastroenterology & Hepatology

IBD-what role do Proteobacteria play?

Indrani Mukhopadhya et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

Review Biochemistry & Molecular Biology

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

Tohru Fukai et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Review Microbiology

Eating For Two: How Metabolism Establishes lnterspecies Interactions in the Gut

Michael A. Fischbach et al.

CELL HOST & MICROBE (2011)

Article Gastroenterology & Hepatology

Conventional Medical Management of Inflammatory Bowel Disease

Daniel Burger et al.

GASTROENTEROLOGY (2011)

Article Chemistry, Multidisciplinary

A Biocompatible Oxidation-Triggered Carrier Polymer with Potential in Therapeutics

Kyle E. Broaders et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Review Multidisciplinary Sciences

Intestinal homeostasis and its breakdown in inflammatory bowel disease

Kevin J. Maloy et al.

NATURE (2011)

Review Multidisciplinary Sciences

Genetics and pathogenesis of inflammatory bowel disease

Bernard Khor et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Chemistry and biology of reactive oxygen species in signaling or stress responses

Bryan C. Dickinson et al.

NATURE CHEMICAL BIOLOGY (2011)

Review Biochemistry & Molecular Biology

The oxidative stress of zinc deficiency

David J. Eide

METALLOMICS (2011)

Article Gastroenterology & Hepatology

In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice

Meaghan M. Hunter et al.

GASTROENTEROLOGY (2010)

Article Pharmacology & Pharmacy

Ascorbyl dipalmitate/PEG-lipid nanoparticles as a novel carrier for hydrophobic drugs

Kunikazu Moribe et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

Article Biochemistry & Molecular Biology

Dopamine Induces Ca2+ Signaling in Astrocytes through Reactive Oxygen Species Generated by Monoamine Oxidase

Annika Vaarmann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemical Research Methods

Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue

Christine J. Weydert et al.

NATURE PROTOCOLS (2010)

Editorial Material Gastroenterology & Hepatology

IBD Selective nanoparticle adhesion can enhance colitis therapy

Alf Lamprecht

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2010)

Review Oncology

The effects of β-glucan on human immune and cancer cells

Godfrey Chi-Fung Chan et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2009)

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Nrf2-Mediated Antioxidant Response

Wenge Li et al.

MOLECULAR CARCINOGENESIS (2009)

Article Immunology

Annexin A1 and glucocorticoids as effectors of the resolution of inflammation

Mauro Perretti et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma

Christopher I. van de Wetering et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Gastroenterology & Hepatology

W1233 A Lecithinized Superoxide Dismutase (PC-SOD) Improves Ulcerative Colitis

Susumu Okamoto et al.

GASTROENTEROLOGY (2008)

Review Gastroenterology & Hepatology

Current Directions in IBD Therapy: What Goals Are Feasible With Biological Modifiers?

William J. Sandborn

GASTROENTEROLOGY (2008)

Review Multidisciplinary Sciences

From endoplasmic-reticulum stress to the inflammatory response

Kezhong Zhang et al.

NATURE (2008)

Review Biochemistry & Molecular Biology

Reconciling the chemistry and biology of reactive oxygen species

Christine C. Winterbourn

NATURE CHEMICAL BIOLOGY (2008)

Article Multidisciplinary Sciences

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Immunology

Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract

Kazuhito Rokutan et al.

SEMINARS IN IMMUNOPATHOLOGY (2008)

Editorial Material Gastroenterology & Hepatology

Role of cytokines in inflammatory bowel disease

Fausto Sanchez-Munoz et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

Article Gastroenterology & Hepatology

Effects of nanocrystalline silver (NPI 32101) in a rat model of ulcerative colitis

Kailash C. Bhol et al.

DIGESTIVE DISEASES AND SCIENCES (2007)

Review Physiology

Nitric oxide and peroxynitrite in health and disease

Pal Pacher et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Pharmacology & Pharmacy

Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung

L. A. Dailey et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2006)

Article Gastroenterology & Hepatology

Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities

SB Hanauer

INFLAMMATORY BOWEL DISEASES (2006)

Review Pharmacology & Pharmacy

New oral delivery systems for treatment of inflammatory bowel disease

DR Friend

ADVANCED DRUG DELIVERY REVIEWS (2005)

Review Cell Biology

Reactive oxygen species in vascular biology: implications in hypertension

RM Touyz et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2004)

Article Medicine, Research & Experimental

Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling

C Nathan

JOURNAL OF CLINICAL INVESTIGATION (2003)

Review Pharmacology & Pharmacy

Microbially triggered drug delivery to the colon

VR Sinha et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2003)

Article Cardiac & Cardiovascular Systems

Superoxide production and expression of Nox family proteins in human atherosclerosis

D Sorescu et al.

CIRCULATION (2002)

Article Gastroenterology & Hepatology

Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis

J Carrier et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2001)

Article Biochemistry & Molecular Biology

Prooxidant and antioxidant activities of bilirubin and its metabolic precursor biliverdin: a structure-activity study

SF Asad et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2001)

Review Multidisciplinary Sciences

Oxidants, oxidative stress and the biology of ageing

T Finkel et al.

NATURE (2000)