The mechanism of nanozyme activity of ZnO-Co3O4_ v: Oxygen vacancy dynamic change and bilayer electron transfer pathway for wound healing and virtual reality revealing

Since the catalyst's surface was the major active location, the inner structure's contribution to catalytic activity was typically overlooked. Here, ZnO-Co3O4_v nanozymes with several surfaces and bulk oxygen vacancies were created. The O atoms of H2O2 moved inward to preferentially fill the oxygen vacancies in the interior and form new lattice oxygen by the X-ray photoelectron spectroscopy depth analysis and X-ray absorption fine structure. The internal Co2} continually transferred electrons to the surface for a continuous catalytic reaction, which generated a significant amount of reactive oxygen species. Inner and outer double-layer electron cycles accompanied this process. A three-dimensional model of ZnO-Co3O4_v was constructed using virtual reality interactive modelling technology to illustrate nanozyme catalysis. Moreover, the bactericidal rate of ZnO-Co3O4_v for Methionine-resistant Staphylococcus aureus and Multiple drug resistant Escherichia coli was as high as 99%. ZnO-Co3O4_v was biocompatible and might be utilized to heal wounds following Methionine-resistant Staphylococcus aureus infection. This work offered a new idea for nanozymes to replace of conventional anti-bacterial medications.

Automated summary

By creating ZnO-Co3O4_v nanozymes with multiple surfaces and bulk oxygen vacancies, the contribution of the inner structure to catalytic activity, which is often overlooked, was discovered. The movement of oxygen atoms of H2O2 inward to fill the oxygen vacancies in the interior and the formation of new lattice oxygen were observed. Internal Co2+ continuously transferred electrons to the surface for continuous catalysis, generating a significant amount of reactive oxygen species. This work provided a novel idea for nanozymes to replace conventional antibacterial medications.