Fabrication of graphene oxide/copper synergistic antibacterial coating for medical titanium substrate

Titanium (Ti) was an excellent medical metal material, but the lack of good antibacterial activity confined its further practical application. To solve this dilemma, a coating containing graphene oxide (GO) and copper (Cu) was prepared on the surface of Ti sheet (Ti/APS/GO/Cu). First, physical sterilization could be carried out through the sharp-edged sheet structure of GO. Second, the oxygen-containing functional group on the surface of GO and the released Cu2+ would generate reactive oxygen species for chemical sterilization. The synergistic effect of GO and Cu substantially enhanced the in vitro and in vivo antibac-terial property of Ti sheet, thereby reducing bacterial-related inflammation. Quantitatively, the antibac-terial rate of Ti/APS/GO/Cu against E. coli or S. aureus reached over 99%. Besides, Ti/APS/GO/Cu showed excellent biocompatibility and no toxicity to cell. Such work developed multiple sterilization avenues to design non-antibiotic, safe and efficient antibacterial implant material for the biomedical domain.(c) 2023 Elsevier Inc. All rights reserved.

Automated summary

A coating containing graphene oxide and copper was prepared on the surface of titanium sheet, which showed excellent antibacterial properties and low toxicity to cells.