Hematological and Other Cancers in People Using Clozapine Analysis of Australian Spontaneous Reports Between 1995 and 2020

Review Pharmacology & Pharmacy

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels

Jose de Leon et al.

Summary: This international guideline suggests improving clozapine package inserts globally by utilizing ancestry-based dosing and gradual titration to prevent potential toxicity and ADRs. It defines six personalized titration schedules for different populations and recommends monitoring inflammation globally.

PHARMACOPSYCHIATRY (2022)

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Article Pharmacology & Pharmacy

Combining Therapeutic Drug Monitoring and Pharmacokinetic Modelling Deconvolutes Physiological and Environmental Sources of Variability in Clozapine Exposure

Kenneth H. Wills et al.

Summary: This study verifies the importance of covariates identified in a prior clozapine population pharmacokinetic model and demonstrates that pharmacokinetic modeling can be used as an adjunct to therapeutic drug monitoring to deconvolute sources of variability in clozapine exposure. Age, metabolic activity, sex, and weight were found to be important physiological covariates associated with variability in clozapine concentrations.

PHARMACEUTICS (2022)

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Article Psychiatry

Long-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case-control and cohort study in Finland

Jari Tiihonen et al.

Summary: The study found that long-term use of clozapine is associated with an increased risk of haematological malignancies compared to other antipsychotic drugs. Patients and caregivers should be informed about warning signs of haematological malignancies, and mental health clinicians should be vigilant for signs and symptoms of haematological malignancy in patients treated with clozapine.

LANCET PSYCHIATRY (2022)

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Article Psychology, Clinical

Haematologic malignancies associated with clozapine v. all other antipsychotic agents: a pharmacovigilance study in VigiBase(R)

Basile Chretien et al.

Summary: The study found a significant association between clozapine and malignant lymphoma and leukemia, with patients in the clozapine treatment group being significantly younger for these hematologic malignancies. There was also a dose-dependent relationship between the dose of clozapine and the risk of developing these malignancies.

PSYCHOLOGICAL MEDICINE (2021)

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Review Psychiatry