Journal
JOURNAL OF CLINICAL PERIODONTOLOGY
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/jcpe.13792
Keywords
dental health; periodontitis; secondary cardiovascular prevention
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This study aimed to investigate the relationship between dental health and incident cardiovascular disease (CVD) in patients with known CVD. The results showed that missing teeth were associated with a higher risk of major adverse cardiovascular events (MACE), and the risk increased with the number of missing teeth.
Aim: To investigate the association between dental health and incident cardiovascular disease (CVD) in secondary prevention setting.Materials and Methods: A total of 888 patients with known CVD hospitalized in the cardiology unit were prospectively enrolled. We assessed the association between missing teeth and three variables of periodontitis and major adverse cardiovascular events (MACE), defined as a composite of cardiac death, acute myocardial infarction, stroke and hospital re-admission for congestive heart failure.Results: During a median (Q1, Q3) follow-up of 4.6 (1.4, 6.7) years, an additional missing tooth was associated with a 3% (95% confidence interval [CI]: 1%-5%) higher hazard of MACE (p = .004). Compared with patients with 0 to <= 4 missing teeth, periods free from MACE (95% CI) by 5 years of follow-up were, on average, shorter by 0.17 (-0.04 to 0.37) years, 0.26 (0.04-0.49) years and 0.59 (0.34-0.85) years in patients with 5 to <= 7, 8 to <= 13 and > 13 missing teeth, respectively. No significant associations were observed between periodontal measures and MACE incidence.Conclusions: In hospitalized patients with existing CVD, the total number of missing teeth was associated with incident MACE.
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