Multicenter Clinical Performance Evaluation of Omadacycline Susceptibility Testing of Enterobacterales on VITEK 2 Systems

Article Pharmacology & Pharmacy

Omadacycline Oral Dosing and Pharmacokinetics in Community-Acquired Bacterial Pneumonia and Acute Bacterial Skin and Skin Structure Infection

Ira M. Leviton et al.

Summary: Omadacycline, a first-in-class aminomethylcycline antibiotic, is approved in the USA for the treatment of adults with community-acquired bacterial pneumonia (CABP) or acute bacterial skin and skin structure infections (ABSSSI). Studies show that dose adjustments are not necessary based on various patient factors, and both oral and intravenous doses have been shown to provide equivalent exposure. Oral loading-dose regimen achieves efficacy targets by Day 2 of treatment and has demonstrated clinical efficacy and good tolerability. The use of oral-only dosing regimens allows for treatment within a hospital or community setting, potentially reducing hospital stay and treatment costs.

CLINICAL DRUG INVESTIGATION (2022)

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Review Medicine, General & Internal

Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance

Kerry L. LaPlante et al.

Summary: The progressive increase in antibiotic resistance in recent decades has led to the urgent development of new antibiotics and antibiotic stewardship programs. Three new tetracycline-class antibiotics have been approved within the past 15 years, representing a new era in the use of tetracyclines. These drugs overcome the main mechanisms of resistance and have a broad spectrum of activity. This article provides an overview of their efficacy, safety, and clinical utility, and discusses various scenarios where patients might benefit from using tetracycline-class antibiotics.

ANNALS OF MEDICINE (2022)

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Review Microbiology

Mobile Tigecycline Resistance: An Emerging Health Catastrophe Requiring Urgent One Health Global Intervention

Madubuike Umunna Anyanwu et al.

Summary: Mobile tigecycline resistance poses a threat to the clinical effectiveness of tigecycline in treating deadly infections caused by superbugs. It is important to raise awareness of plasmid-mediated resistance and the need for global intervention.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Respiratory System

The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic

Daniel Reynolds et al.

Summary: Antibiotic resistance is a global threat to human health, especially the increasing resistance to available antimicrobial agents among Gram-negative bacteria, which can lead to the presence of multidrug-resistant (MDR) and extremely drug-resistant (XDR) pathogens. This concern is further escalated by the identification of these MDR/XDR Gram-negative bacteria in water and food sources, as colonisers of the intestine, and as agents of various infections. Pneumonia and other respiratory infections caused by MDR/XDR Gram-negative bacteria are common and associated with high mortality rates. The emergence of resistance to existing antimicrobial agents developed in the past decade and the scarcity of novel agents in the developmental pipeline increase the likelihood of a future pandemic caused by MDR/XDR Gram-negative bacteria.

EUROPEAN RESPIRATORY REVIEW (2022)

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Review Medicine, General & Internal

Advances in novel antibiotics to treat multidrug-resistant gram-negative bacterial infections

Aaron Matlock et al.

Summary: Antimicrobial resistance poses a growing threat to public health, making it increasingly important for acute care physicians to be familiar with novel antibiotics for appropriate utilization in combating infections caused by resistant gram-negative bacteria in the acute care setting.

INTERNAL AND EMERGENCY MEDICINE (2021)

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Review Pharmacology & Pharmacy