Flexible approaches to clinical trials

Review Health Care Sciences & Services

A systematic scoping review of just-in-time, adaptive interventions finds limited automation and incomplete reporting

Theodora Oikonomidi et al.

Summary: A systematic scoping review was conducted to assess the degree of automation and completeness of intervention reporting in randomized controlled trials of just-in-time, adaptive interventions. The results show that most interventions are not fully automated and require involvement from healthcare professionals and patients.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2023)

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Review Health Care Sciences & Services

Reporting quality was suboptimal in a systematic review of randomized controlled trials with adaptive designs

Sujata Purja et al.

Summary: The objective of this study was to evaluate the reporting quality of randomized controlled trials (RCTs) using adaptive design (AD) based on the 2020 AD Consolidated Standards for Reporting Trials 2010 extension (ACE) guidelines. A total of 109 RCTs were included in the study, and the mean compliance rate for the ACE checklist items was found to be 69.75% ± 16.02. Key methodological items, such as allocation concealment, were poorly reported, and there was suboptimal reporting of checklist items related to interim analyzes. The study concluded that stricter adherence to the ACE guidelines is necessary to improve the reporting quality of RCTs with AD.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2023)

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Article Medicine, General & Internal